ATLAS OF RENAL PATHOLOGY

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Acute Tubular Necrosis

Pathology Editor: Agnes Fogo, MD
Medical Photographer: Brent Weedman

 
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Fig 1. Acute tubular necrosis may be manifest only by regenerating flattened tubular epithelium without frank necrosis of individual tubular cells, as shown in some tubules to the right of the glomerulus, by bleebbing and individual cell degenration (top left), or by frank necrosis ( middle). There is minimal accompanying interstitial infiltrate (periodic acid Schiff stain, x 100).
 
 
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Fig 2. There may also be degeneration and frank necrosis of individual cells or tubular segments in acute tubular necrosis, or flattened, regenerating type epithelium with degenerated cells in the lumen (middle left) (hematoxylin and eosin, x 200).
 
 
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Fig 3. Acute tubular necrosis is manifest by vacuolated cells and sloughed, necrotic cells in tubular lumina, with some tubules lined by flattened epithelium and some showing frank necrosis (periodic acid Schiff stain, x 400).
 

From the Department of Pathology, Vanderbilt University Medical Center, Nashville, TN.
Address author queries to Agnes Fogo, MD, Department of Pathology, Vanderbilt University Medical Center, MCN C-3310, Nashville, TN 37232. E-mail:Agnes.Fogo@vanderbilt.edu
 Copyright 2003 by the National Kidney Foundation, Inc.

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