ATLAS OF RENAL PATHOLOGY

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Cytomegalovirus Infection

Pathology Editor: Agnes Fogo, MD
Medical Photographer: Brent Weedman

 
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Fig 1. Cytomegalovirus infection is diagnosed by the appearance of large cells with basophilic enlarged nuclei with inclusions. There is frequent tubular injury and degeneration. Cytomegalovirus infection most commonly affects tubular epithelial cells and occurs most commonly in the transplant. (Hematoxylin and eosin, original magnification X100).
 
 
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Fig 2. The marked enlargement of the tubular epithelial cells with markedly enlarged nuclei and degeneration is evident in this case of cytomegalovirus infection in the transplant. (Hematoxylin and eosin, original magnification X1,000).
 
 
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Fig 3. Cytomegalovirus infection may also rarely involve the glomerulus, as in this transplant patient where there is marked enlargement of visceral epithelial cells with enlarged nuclei and owls'eye type nuclear inclusions (left). (Hematoxylin and eosin, original magnification X400).
 
 
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Fig 4. Cytomegalovirus can also be seen by electron microscopy. The virus has a typical bull's eye appearance when present in the cytoplasm, where it has picked up an extra layer of the nuclear membrane. (Transmission electron microscopy, original magnification X200,000).
 

From the Department of Pathology, Vanderbilt University Medical Center, Nashville, TN.
Address author queries to Agnes Fogo, MD, Department of Pathology, Vanderbilt University Medical Center, MCN C-3310, Nashville, TN 37232. E-mail:Agnes.Fogo@vanderbilt.edu
Am J Kidney Dis 36(2):E7, 2000 (available www.ajkd.org)
 Copyright 2000 by the National Kidney Foundation, Inc.

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