ATLAS OF RENAL PATHOLOGY

The Atlas of Renal Pathology presents a compilation of figures on a specific pathologic entity. You should read the Terms and Conditions of Use before using this site. If you agree to the terms, you may download the figures to create your own personal, noncommercial library of images or to create slides for teaching purposes.

To view a larger version of each figure, select View larger version below each figure. To make a slide, select download slide-quality image file. Download times may be somewhat lengthy. For tips on preparing slides from the files, please see Downloading Images for Slide Preparation.

Alport's Syndrome

Pathology Editor: Agnes Fogo, MD
Medical Photographer: Brent Weedman

 
View larger version
Download slide-quality image
Fig 1. In stages of Alport's Syndrome where renal insufficiency is manifest, glomerulosclerosis may be present in segmental or global patterns with proportional interstitial fibrosis, as shown in this case. No deposits are present by immunofluorescence, and the specific diagnosis must be made by electron microscopy. (Jones' Silver Stain, original magnification X100).
 
 
View larger version
Download slide-quality image
Fig 2. Interstitial foamy macrophages were previously thought to be a sign indicative of Alport's Syndrome. However, it is now recognized that this lesion is present in many conditions with proteinuria, and electron microscopy is necessary to specifically diagnose Alport's Syndrome. (Periodic Acid-Schiff Stain, original magnification X100).
 
 
View larger version
Download slide-quality image
Fig 3. In Alport's Syndrome, the glomerular basement membrane shows irregular thinning and thickening with a lamellated basket-weave appearance in the thickened area due to extensive remodeling and injury of the basement membrane. In cases with proteinuria, there may be moderate foot process effacement. No immune complexes are present. (Transmission electron microscopy, original magnification X6,000).
 
 
View larger version
Download slide-quality image
Fig 4. By high power, the basket-weave, lamellated appearance of the glomerular basement membrane is readily apparent in this case of Alport's Syndrome. There may also be interposition as illustrated. In other areas, the basement membrane may show only attenuation. (Transmission electron microscopy, original magnification X10,000).
 

From the Department of Pathology, Vanderbilt University Medical Center, Nashville, TN.
Address author queries to Agnes Fogo, MD, Department of Pathology, Vanderbilt University Medical Center, MCN C-3310, Nashville, TN 37232. E-mail:Agnes.Fogo@vanderbilt.edu
Am J Kidney Dis 35(1):E1, 2000 (available www.ajkd.org)
 Copyright 2000 by the National Kidney Foundation, Inc.

Home | Help | Feedback | Subscription | Archive | Search | Atlas Home
Home Help Feedback Subscriptions Archive Search Atlas Home