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Hypertensive Nephrosclerosis

Pathology Editor: Agnes Fogo, MD
Medical Photographer: Brent Weedman
With Assistance From: Kim Solez, MD, of the National Kidney Foundation's cyberNephrologyTM Team

 
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Fig 1. Hypertensive nephrosclerosis is characterized by medial thickening and intimal fibrosis of medium-sized and larger vessels, arteriolar thickening, and hyalinosis, frequently associated with global glomerulosclerosis with obsolescence of glomeruli, as shown here. There is proportional tubulointerstitial fibrosis. (Periodic acid-Schiff stain, original magnification X100).
 
 
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Fig 2. Hyalinosis is evident in the arteriole and interlobular artery in hypertensive nephrosclerosis, along with mild medial thickening caused by both hypertrophy and hyperplasia of vascular smooth muscle cells. The hyalin material is the result of insudation of plasma proteins, and is pink and glassy-smooth in appearance (ie, hyalin). (Periodic acid-Schiff stain, original magnification X200).
 
 
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Fig 3. Intimal fibrosis as well as medial thickening is evident in this artery in a patient with hypertensive nephrosclerosis. (Periodic acid-Schiff stain, original magnification X200).
 

From the Department of Pathology, Vanderbilt University Medical Center, Nashville, TN.
Address author queries to Agnes Fogo, MD, Department of Pathology, Vanderbilt University Medical Center, MCN C-3310, Nashville, TN 37232. E-mail:Agnes.Fogo@vanderbilt.edu
Am J Kidney Dis 33(6):E1, 1999 (available www.ajkd.org)
 Copyright 1999 by the National Kidney Foundation, Inc.

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