ATLAS OF RENAL PATHOLOGY

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Minimal Change Disease

Pathology Editor: Agnes Fogo, MD
Medical Photographer: Brent Weedman
With Assistance From Kim Solez, MD, of the National Kidney Foundation's cyberNephrologyTM Team

 
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Fig 1. Glomeruli are normal by light microscopy in minimal change disease, as shown in this biopsy. The glomerular basement membrane is thin and delicate, and mesangial cellularity and matrix are within normal limits. There was no interstitial fibrosis and no segmental sclerosis in any of the glomeruli sampled. However, the possibility of unsampled focal segmental glomerulosclerosis (FSGS) cannot be completely excluded when only a small number of glomeruli (less than 250) are examined. (Jones' silver stain, X200).
 
 
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Fig 2. The glomerular basement membrane is of normal thickness without deposits in this case of minimal change disease. The visceral epithelial cells show diffuse effacement of foot processes. An area of microvillous transformation is also present, representing the irregular epithelial-cell surface that occurs in proteinuric states. Foot-process effacement is generally quite extensive in minimal change disease, although the degree of foot-process effacement cannot be used to definitively distinguish minimal change disease from unsampled FSGS. (Transmission electron microscopy, X800).
 

From the Department of Pathology, Vanderbilt University Medical Center, Nashville, TN.
Address author queries to Agnes Fogo, MD, Department of Pathology, Vanderbilt University Medical Center, MCN C-3310, Nashville, TN 37232. E-mail:Agnes.Fogo@vanderbilt.edu
Am J Kidney Dis 33(3):E1, 1999 (available www.ajkd.org)
 Copyright 1999 by the National Kidney Foundation, Inc.

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