The Atlas of Renal Pathology presents a compilation of figures on a specific pathologic entity. You should read the Terms and Conditions of Use before using this site. If you agree to the terms, you may download the figures to create your own personal, noncommercial library of images or to create slides for teaching purposes.

To view a larger version of each figure, select View larger version below each figure. To make a slide, select download slide-quality image file. Download times may be somewhat lengthy. For tips on preparing slides from the files, please see Downloading Images for Slide Preparation.

Minimal Change Disease

Pathology Editor: Agnes Fogo, MD
Medical Photographer: Brent Weedman
With Assistance From Kim Solez, MD, of the National Kidney Foundation's cyberNephrologyTM Team

View larger version
Download slide-quality image
Fig 1. Glomeruli are normal by light microscopy in minimal change disease, as shown in this biopsy. The glomerular basement membrane is thin and delicate, and mesangial cellularity and matrix are within normal limits. There was no interstitial fibrosis and no segmental sclerosis in any of the glomeruli sampled. However, the possibility of unsampled focal segmental glomerulosclerosis (FSGS) cannot be completely excluded when only a small number of glomeruli (less than 250) are examined. (Jones' silver stain, X200).
View larger version
Download slide-quality image
Fig 2. The glomerular basement membrane is of normal thickness without deposits in this case of minimal change disease. The visceral epithelial cells show diffuse effacement of foot processes. An area of microvillous transformation is also present, representing the irregular epithelial-cell surface that occurs in proteinuric states. Foot-process effacement is generally quite extensive in minimal change disease, although the degree of foot-process effacement cannot be used to definitively distinguish minimal change disease from unsampled FSGS. (Transmission electron microscopy, X800).

From the Department of Pathology, Vanderbilt University Medical Center, Nashville, TN.
Address author queries to Agnes Fogo, MD, Department of Pathology, Vanderbilt University Medical Center, MCN C-3310, Nashville, TN 37232.
Am J Kidney Dis 33(3):E1, 1999 (available
 Copyright 1999 by the National Kidney Foundation, Inc.

Home | Help | Feedback | Subscription | Archive | Search | Atlas Home
Home Help Feedback Subscriptions Archive Search Atlas Home