ATLAS OF RENAL PATHOLOGY

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MESANGIAL LUPUS NEPHRITIS

Pathology Editor: Agnes Fogo, MD
Medical Photographer: Brent Weedman
With Assistance From Kim Solez, MD, of the National Kidney Foundation's cyberNephrologyTM Team

 
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Fig 1. Mesangial lupus nephritis (WHO Class IIb) shows mild mesangial expansion by light microscopy, without evidence of endocapillary proliferation. If mesangial immune complexes are present but no mesangial increase is detected by light microscopy, WHO Class IIa is diagnosed (PAS stain; original magnification x200).
 
 
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Fig 2. Immunofluorescence shows mesangial staining in WHO Class IIb lupus nephritis, without peripheral capillary loop deposits (immunofluorescence with anti-IgM; original magnification x400).
 
 
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Fig 3. Electron-dense mesangial deposits are present in mesangial lupus nephritis WHO Class IIb. There is paramesangial extension of a deposit in the upper left, indicating incipient progression to a proliferative form of lupus nephritis. Reticular aggregates are also present in endothelial cell cytoplasm (transmission electron microscopy; original magnification x8,000).
 

From the Department of Pathology, Vanderbilt University Medical Center, Nashville, TN.
Address author queries to Agnes Fogo, MD, Department of Pathology, Vanderbilt University Medical Center, MCN C-3310, Nashville, TN 37232. E-mail:Agnes.Fogo@vanderbilt.edu
Am J Kidney Dis 32(1):E1, 1998 (available www.ajkd.org)
 Copyright 1998 by the National Kidney Foundation, Inc.

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