| Trial Design |
| |
Article Title |
Author(s) |
Pages |
|
|
|
GENESIS-PRAXY (GENdEr and Sex determInantS of cardiovascular disease: From bench to beyond-Premature Acute Coronary SYndrome)
Background: Previous research has not adequately addressed the topic of sex and gender differences in occurrence of premature acute coronary syndrome (ACS). This study will investigate the clinical pr...
|
Louise Pilote,
Igor Karp
|
741-746.e2
|
|
|
|
A novel algorithm for individualized cardiac resynchronization therapy: Rationale and design of the adaptive cardiac resynchronization therapy trial
Background: The magnitude of benefit of cardiac resynchronization therapy (CRT) varies significantly among its recipients; approximately 30% of CRT patients do not report clinical improvement. Optimiz...
|
Henry Krum,
Bernd Lemke,
David Birnie,
Kathy Lai-Fun Lee,
Kazutaka Aonuma,
Randall C. Starling,
Maurizio Gasparini,
John Gorcsan,
Tyson Rogers,
Alex Sambelashvili,
Amy Kalmes,
David Martin
et al.
|
747-752.e1
|
|
|
|
Rationale and design of the PRAETORIAN trial: A Prospective, RAndomizEd comparison of subcuTaneOus and tRansvenous ImplANtable cardioverter-defibrillator therapy
Background: Implantable cardioverter-defibrillators (ICDs) are widely used to prevent fatal outcomes associated with life-threatening arrhythmic episodes in a variety of cardiac diseases. These ICDs r...
|
Louise R.A. Olde Nordkamp,
Reinoud E. Knops,
Gust H. Bardy,
Yuri Blaauw,
Lucas V.A. Boersma,
Johannes S. Bos,
Peter Paul H.M. Delnoy,
Pascal F.H.M. van Dessel,
Antoine H.G. Driessen,
Joris R. de Groot,
Jean Paul R. Herrman,
Luc J.L.M. Jordaens,
Kirsten M. Kooiman,
Alexander H. Maass,
Mathias Meine,
Yuka Mizusawa,
Sander G. Molhoek,
Jurjen van Opstal,
Jan G.P. Tijssen,
Arthur A.M. Wilde
et al.
|
753-760.e2
|
|
|
|
Rationale and design of a randomized study to determine the value of central Blood Pressure for GUIDing managEment of hypertension: The BP GUIDE study
Background: Noninvasive estimates of central blood pressure (BP) predict cardiovascular morbidity and mortality independent of brachial BP. However, there are limited data on the usefulness of central...
|
James E. Sharman,
Thomas H. Marwick,
Walter P. Abhayaratna,
Michael Stowasser
|
761-767
|
|
|
|
Rationale and design of the Cangrelor versus standard therapy to acHieve optimal Management of Platelet InhibitiON PHOENIX trial
Background: Despite robust efficacy in the reduction of ischemic events in patients who require percutaneous coronary intervention (PCI), current P2Y12 inhibitors have limitations. In particular, they...
|
Sergio Leonardi,
Kenneth W. Mahaffey,
Harvey D. White,
C. Michael Gibson,
Gregg W. Stone,
Gabriel W. Steg,
Christian W. Hamm,
Matthew J. Price,
Meredith Todd,
Markus Dietrich,
Dianne Gallup,
Tiepu Liu,
Simona Skerjanec,
Robert A. Harrington,
Deepak L. Bhatt
et al.
|
768-776.e2
|
|
| Clinical Investigations |
| Acute Ischemic Heart Disease |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treatment of ischemic heart disease: Future research needs prioritization
Background: A recent review evaluated the comparative effectiveness of angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin II receptor blockers (ARBs) in patients with or at high risk fo...
|
Matthew J. Crowley,
Benjamin J. Powers,
Evan R. Myers,
Amanda J. McBroom,
Gillian D. Sanders
et al.
|
777-782.e8
|
|
|
|
Multiple biomarkers at admission are associated with angiographic, electrocardiographic, and imaging cardiovascular mechanistic markers of outcomes in patients undergoing primary percutaneous coronary intervention for acute ST-elevation myocardial infarction
Background: The multimarker risk score, based on estimated glomerular filtration rate, glucose, and N-terminal probrain natriuretic peptide (NT-proBNP), has been shown to predict mortality in patients...
|
Peter Damman,
Wichert J. Kuijt,
Pier Woudstra,
Joost D.E. Haeck,
Karel T. Koch,
Youlan L. Gu,
Jan P. van Straalen,
Johan Fischer,
Jan G.P. Tijssen,
Mitchell W. Krucoff,
Robbert J. de Winter
et al.
|
783-789
|
|
|
|
Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry
Background: Acute myocardial infarction (AMI) may contribute to health status declines including “independence loss” and “physical function decline.” Despite the importance of these outcomes for progn...
|
John A. Dodson,
Suzanne V. Arnold,
Kimberly J. Reid,
Thomas M. Gill,
Michael W. Rich,
Frederick A. Masoudi,
John A. Spertus,
Harlan M. Krumholz,
Karen P. Alexander
et al.
|
790-796
|
|
|
|
Variations in practice and outcomes in patients undergoing primary percutaneous coronary intervention in the United States and Canada: Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX AMI) trial
Background: Information on practice patterns and outcomes in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary interventions (PCIs) in Canada vs United States i...
|
Rajendra H. Mehta,
Padma Kaul,
Renato D. Lopes,
Manesh R. Patel,
Yinggan Zheng,
Karen S. Pieper,
Robert C. Welsh,
Paul W. Armstrong,
Christopher B. Granger
et al.
|
797-803
|
|
| Congestive Heart Failure |
| |
Article Title |
Author(s) |
Pages |
|
|
|
International variation in use of oral anticoagulation among heart failure patients with atrial fibrillation
29 March 2012
Background: We sought to characterize patient factors and regional variations associated with vitamin K antagonist (VKA) use in patients with heart failure (HF) and atrial fibrillation (AF) in areas o...
|
Jorge Suarez,
Jonathan P. Piccini,
Li Liang,
John J. Atherton,
Christopher S. Hayward,
Henry Krum,
Gregg C. Fonarow,
Renato D. Lopes,
Adrian F. Hernandez
et al.
|
804-811
|
|
|
|
Percutaneous left ventricular partitioning in patients with chronic heart failure and a prior anterior myocardial infarction: Results of the PercutAneous Ventricular RestorAtion in Chronic Heart failUre PaTiEnts Trial
Objectives: The aim of this study was to assess the feasibility, safety, and preliminary efficacy of a novel percutaneous left ventricular partitioning device (VPD) in patients with chronic heart fail...
|
Ernest L. Mazzaferri,
Sinisa Gradinac,
Dragan Sagic,
Petar Otasevic,
Ayesha K. Hasan,
Thomas L. Goff,
Horst Sievert,
Nina Wunderlich,
Serjan D. Nikolic,
William T. Abraham
et al.
|
812-820.e1
|
|
|
|
Combined use of high-sensitivity cardiac troponin T and N-terminal pro-B type natriuretic peptide improves measurements of performance over established mortality risk factors in chronic heart failure
Background: Heart failure still maintains a high mortality. Biomarkers reflecting different pathophysiological pathways are under evaluation to better stratify the mortality risk. The objective was to...
|
Marta de Antonio,
Josep Lupon,
Amparo Galan,
Joan Vila,
Agustin Urrutia,
Antoni Bayes-Genis
et al.
|
821-828
|
|
| Interventional Cardiology |
| |
Article Title |
Author(s) |
Pages |
|
|
|
The changing definition of contrast-induced nephropathy and its clinical implications: Insights from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2)
Background: The traditional definition of contrast-induced nephropathy (CIN) has been an absolute rise of serum creatinine (Cr) of ≥0.5 mg/dL, although most recent clinical trials have included a ≥25%...
|
Nicklaus K. Slocum,
P. Michael Grossman,
Mauro Moscucci,
Dean E. Smith,
Herbert D. Aronow,
Simon R. Dixon,
David Share,
Hitinder S. Gurm
et al.
|
829-834
|
|
|
|
Assessing the role of eptifibatide in patients with diffuse coronary disease undergoing drug-eluting stenting: The INtegrilin plus STenting to Avoid myocardial Necrosis Trial
Background: The optimal antiplatelet regimen in elective patients undergoing complex percutaneous coronary interventions (PCIs) is uncertain. We aimed to assess the impact of glycoprotein IIb/IIIa (Gp...
|
Giuseppe Biondi-Zoccai,
Marco Valgimigli,
Massimo Margheri,
Antonio Marzocchi,
Corrado Lettieri,
Amerigo Stabile,
A. Sonia Petronio,
Giorgio Binetti,
Leonardo Bolognese,
Pietro Bellone,
Gennaro Sardella,
Marco Contarini,
Imad Sheiban,
Sebastiano Marra,
Federico Piscione,
Francesco Romeo,
Antonio Colombo,
Giuseppe Sangiorgi
et al.
|
835.e1-835.e7
|
|
| Outcomes, Health Policy and Managed Care |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Understanding childhood obesity in America: Linkages between household income, community resources, and children's behaviors
Background: Understanding childhood obesity's root causes is critical to the creation of strategies to improve our children's health. We sought to define the association between childhood obesity and ...
|
Taylor F. Eagle,
Anne Sheetz,
Roopa Gurm,
Alan C. Woodward,
Eva Kline-Rogers,
Robert Leibowitz,
Jean DuRussel-Weston,
LaVaughn Palma-Davis,
Susan Aaronson,
Catherine M. Fitzgerald,
Lindsey R. Mitchell,
Bruce Rogers,
Patricia Bruenger,
Katherine A. Skala,
Caren Goldberg,
Elizabeth A. Jackson,
Steven R. Erickson,
Kim A. Eagle
et al.
|
836-843
|
|
| Coronary Artery Disease |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease
Background: Cardiovascular risk models remain incomplete. Small-molecule metabolites may reflect underlying disease and, as such, serve as novel biomarkers of cardiovascular risk. Methods: We studied ...
|
Svati H. Shah,
Jie-Lena Sun,
Robert D. Stevens,
James R. Bain,
Michael J. Muehlbauer,
Karen S. Pieper,
Carol Haynes,
Elizabeth R. Hauser,
William E. Kraus,
Christopher B. Granger,
Christopher B. Newgard,
Robert M. Califf,
L. Kristin Newby
et al.
|
844-850.e1
|
|
| Valvular and Congenital Heart Disease |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Retrospective cohort analysis of 926 tricuspid valve surgeries: Clinical and hemodynamic outcomes with propensity score analysis
Background: The objectives were to describe morbidity and mortality after tricuspid valve (TV) surgery, to compare outcomes after repair versus replacement, and to assess risk factors for mortality an...
|
Guillaume Marquis-Gravel,
Denis Bouchard,
Louis P. Perrault,
Pierre Pagé,
Hugues Jeanmart,
Philippe Demers,
Michel Carrier,
Raymond Cartier,
Nancy C. Poirier,
Yves Hébert,
Michel Pellerin
et al.
|
851-858.e1
|
|
|
|
Systemic right ventricular longitudinal strain is reduced in adults with transposition of the great arteries, relates to subpulmonary ventricular function, and predicts adverse clinical outcome
Background: Transposition of the great arteries (TGA) after atrial switch operation and congenitally corrected TGA (ccTGA) are commonly associated with impaired systemic right ventricular (RV) functio...
|
Gerhard-Paul Diller,
Jelena Radojevic,
Aleksander Kempny,
Rafael Alonso-Gonzalez,
Liodakis Emmanouil,
Stefan Orwat,
Lorna Swan,
Anselm Uebing,
Wei Li,
Konstantinos Dimopoulos,
Michael A. Gatzoulis,
Helmut Baumgartner
et al.
|
859-866
|
|
| Diabetes and Metabolism |
| |
Article Title |
Author(s) |
Pages |
|
|
|
The SPIRIT V Diabetic Study: A randomized clinical evaluation of the XIENCE V everolimus-eluting stent vs the TAXUS Liberté paclitaxel-eluting stent in diabetic patients with de novo coronary artery lesions
12 April 2012
Background: Diabetic patients respond less favorably to revascularization and have poorer long-term outcomes. Our main aim was to evaluate the angiographic efficacy of XIENCE V (everolimus-eluting ste...
|
Eberhard Grube,
Bernard Chevalier,
Giulio Guagliumi,
Peter C. Smits,
Marrianne Stuteville,
Cécile Dorange,
Peggy Papeleu,
Upendra Kaul,
Vladimír Džavík
et al.
|
867-875.e1
|
|
|
|
Long-term clinical and angiographic outcomes of diabetic patients after revascularization with early generation drug-eluting stents
Background: Early generation drug-eluting stents (DESs) reduce restenosis and repeat revascularization procedures. However, the long-term safety and efficacy of early generation DES according to diabe...
|
Michael Billinger,
Lorenz Räber,
Sarah Hitz,
Giulio G. Stefanini,
Thomas Pilgrim,
Christoph Stettler,
Thomas Zanchin,
Cedric Pulver,
Nico Pfäffli,
Franz Eberli,
Bernhard Meier,
Bindu Kalesan,
Peter Jüni,
Stephan Windecker
et al.
|
876-886.e2
|
|
| Electrophysiology |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Progression of atrial fibrillation in the REgistry on Cardiac rhythm disORDers assessing the control of Atrial Fibrillation cohort: Clinical correlates and the effect of rhythm-control therapy
Introduction: Paroxysmal atrial fibrillation (AF) may progress to persistent AF. We studied the clinical correlates and the effect of rhythm-control strategy on AF progression. Methods: RecordAF was a...
|
Cees B. De Vos,
Günter Breithardt,
A. John Camm,
Paul Dorian,
Peter R. Kowey,
Jean-Yves Le Heuzey,
Lisa Naditch-Brûlé,
Eric N. Prystowsky,
Peter J. Schwartz,
Christian Torp-Pedersen,
William S. Weintraub,
Harry J. Crijns
et al.
|
887-893
|
|
| Pediatrics |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Trends in endocarditis hospitalizations at US children's hospitals: Impact of the 2007 American Heart Association Antibiotic Prophylaxis Guidelines
Background: In 2007, the American Heart Association recommended cessation of antibiotic prophylaxis for infective endocarditis (IE) before dental procedures for all but those at highest risk for adver...
|
Sara K. Pasquali,
Xia He,
Zeinab Mohamad,
Brian W. McCrindle,
Jane W. Newburger,
Jennifer S. Li,
Samir S. Shah
et al.
|
894-899
|
|
|
|
Correction
04 April 2012
The article “Causes of death and rehospitalization in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction: Results from efficacy of vasopressin antagonism...
|
|
900
|
|
|
|
Correction
04 April 2012
The article “Familiar transmission of coronary heart disease: a cohort study of 80,214 Swedish adoptees linked to their biological and adoptive parents” (Am Heart J 2011;162:317-323) was published wit...
|
|
901
|
|
| Letters to the Editor |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Regarding the “Platelet reactivity in patients with chronic kidney disease receiving adjunctive cilostazol compared with a high-maintenance dose of clopidogrel: Results of the Effect of Platelet Inhibition According to Clopidogrel Dose in Patients with Chronic Kidney Disease (PIANO-2 CKD) randomized study”
We read, with interest, the work by Woo et al in patients on hemodialysis comparing the effect of clopidogrel 75 mg, 150 mg, or cilostazol on platelet reactivity. The authors describe an efficient pla...
|
Dimitrios Alexopoulos
|
e31
|
|
|
|
Reply to the letter by Alexopoulos et al “Platelet reactivity in patients with chronic kidney disease receiving adjunctive cilostazol compared with a high-maintenance dose of clopidogrel: Results of the Effect of Platelet Inhibition According to Clopidogrel Dose in Patients with Chronic Kidney Disease (PIANO-2 CKD) randomized study”
We thank Dr Alexopoulos for pointing out several issues related to our recent publication on the platelet reactivity to clopidogrel and cilostazol in patients with chronic kidney disease (CKD) with ch...
|
Jong Shin Woo,
Weon Kim
|
e33
|
|
|
|
Intensive glycemic control and the risk of heart failure in patients with type 2 diabetes
Castagno et al conducted a timely meta-analysis of 7 randomized controlled trials to help determine if intensive blood glucose control has benefit in reducing the risk of congestive heart failure (CHF...
|
Sebhat Erquo,
Chee-Tin Christine Lee,
Amanda Adler
|
e35
|
|
|
|
Reply to the letter by Dr Erqou regarding “Intensive glycemic control has no impact on the risk of heart failure in type 2 diabetic patients”
As Dr Erqou points out, we did carefully differentiate between trials with high thiazolidinedione (TZD) use and those without. In addition, we highlighted the potential “off-target” effects of TZDs. H...
|
Davide Castagno,
Jonathan Baird-Gunning,
Pardeep S. Jhund,
Giuseppe Biondi Zoccai,
Michael R. MacDonald,
Mark C. Petrie,
Fiorenzo Gaita,
John J.V. McMurray
et al.
|
e37
|
|
|
|
Preanalytic considerations for using plasma myeloperoxidase as a biomarker in acute coronary syndrome
Thank you for publishing the informative article by Peacock et al in the Journal, which reported the lack of prognostic utility of myeloperoxidase (MPO) as an adjunctive biomarker in acute coronary sy...
|
Regent Lee
|
e39-e40
|
|
|
|
Myeloperoxidase in the diagnosis of acute coronary syndromes: The importance of spectrum
Our results demonstrating the poor performance of myeloperoxidase (MPO) as a diagnostic test should not be unexpected. Myeloperoxidase is found in vulnerable atherosclerotic plaques. The postulate tha...
|
W. Frank Peacock
|
e41
|
|
| Frontmatter |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Table of Contents
|
|
A1-A5
|
|
|
|
Editorial Board
|
|
A8
|
|
|
|
Information for Readers
|
|
A9
|
|
