Journal of Allergy and Clinical Immunology

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Intravenous administration of irinotecan elevates the blood beta-glucuronidase activity in rats.
N Kaneda, A Kurita, Y Hosokawa, T Yokokura, S Awazu
Cancer Res
Dec 1997 (Vol. 57, Issue 23, Pages 5305-8)
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	The role of rat serum carboxylesterase in the activation of paclitaxel and camptothecin prodrugs. P D Senter, H Marquardt, B A Thomas, B D Hammock, I S Frank, H P Svensson Cancer Res Apr 1996 (Vol. 56, Issue 7, Pages 1471-4) MEDLINE \| Related Records
	Secreted and tumour targeted human carboxylesterase for activation of irinotecan. D Oosterhoff, H M Pinedo, I H van der Meulen, M de Graaf, T Sone, F A Kruyt, V W van Beusechem, H J Haisma, W R Gerritsen Br J Cancer Sep 2002 (Vol. 87, Issue 6, Pages 659-64) MEDLINE \| Related Records
	Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity. Janice L Hyatt, Lyudmila Tsurkan, Monika Wierdl, Carol C Edwards, Mary K Danks, Philip M Potter Mol Cancer Ther Sep 2006 (Vol. 5, Issue 9, Pages 2281-8) MEDLINE \| Related Records
	Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase. S M Guichard, C L Morton, E J Krull, C F Stewart, M K Danks, P M Potter Clin Cancer Res Dec 1998 (Vol. 4, Issue 12, Pages 3089-94) MEDLINE \| Related Records
	Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Sonal P Sanghani, Sara K Quinney, Tyler B Fredenburg, Wilhelmina I Davis, Daryl J Murry, William F Bosron Drug Metab Dispos May 2004 (Vol. 32, Issue 5, Pages 505-11) MEDLINE \| Related Records
	Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2. R Humerickhouse, K Lohrbach, L Li, W F Bosron, M E Dolan Cancer Res Mar 2000 (Vol. 60, Issue 5, Pages 1189-92) MEDLINE \| Related Records
	In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors. A Kojima, N R Hackett, A Ohwada, R G Crystal J Clin Invest Apr 1998 (Vol. 101, Issue 8, Pages 1789-96) MEDLINE \| Related Records
	Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro. Keiji Tanimoto, Mika Kaneyasu, Tatsushi Shimokuni, Keiko Hiyama, Masahiko Nishiyama Pharmacogenet Genomics Jan 2007 (Vol. 17, Issue 1, Pages 1-10) MEDLINE \| Related Records
	Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions. J G Slatter, P Su, J P Sams, L J Schaaf, L C Wienkers Drug Metab Dispos Oct 1997 (Vol. 25, Issue 10, Pages 1157-64) MEDLINE \| Related Records
	The relative contributions of carboxylesterase and beta-glucuronidase in the formation of SN-38 in human colorectal tumours. Peter J Tobin, Helen M Dodds, Stephen Clarke, Margaret Schnitzler, Laurent P Rivory Oncol Rep (Vol. 10, Issue 6, Pages 1977-9) MEDLINE \| Related Records
	Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application. Kyoung Jin P Yoon, Janice L Hyatt, Christopher L Morton, Richard E Lee, Philip M Potter, Mary K Danks Mol Cancer Ther Aug 2004 (Vol. 3, Issue 8, Pages 903-9) MEDLINE \| Related Records
	Cellular parameters predictive of the clinical response of colorectal cancers to irinotecan. A preliminary study. Valérie Pavillard, Virginie Charasson, Audrey Laroche-Clary, Isabelle Soubeyran, Jacques Robert Anticancer Res (Vol. 24, Issue 2B, Pages 579-85) MEDLINE \| Related Records
	CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants. W J Jansen, B Zwart, S T Hulscher, G Giaccone, H M Pinedo, E Boven Int J Cancer Jan 1997 (Vol. 70, Issue 3, Pages 335-40) MEDLINE \| Related Records
	Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. Guang Xu, Wanghai Zhang, Margaret K Ma, Howard L McLeod Clin Cancer Res Aug 2002 (Vol. 8, Issue 8, Pages 2605-11) MEDLINE \| Related Records
	Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines. Valérie Pavillard, Cécile Agostini, Sophie Richard, Virginie Charasson, Danièle Montaudon, Jacques Robert Cancer Chemother Pharmacol Apr 2002 (Vol. 49, Issue 4, Pages 329-35) MEDLINE \| Related Records
	Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene. Michael H Wu, Peixian Chen, Xiaolin Wu, Wanqing Liu, Stephen Strom, Soma Das, Edwin H Cook, Gary L Rosner, M Eileen Dolan Pharmacogenetics Sep 2004 (Vol. 14, Issue 9, Pages 595-605) MEDLINE \| Related Records
	Pharmacology of irinotecan. J G Kuhn Oncology (Williston Park) Aug 1998 (Vol. 12, Issue 8 Suppl 6, Pages 39-42) MEDLINE \| Related Records
	The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase. Michal Harel, Janice L Hyatt, Boris Brumshtein, Christopher L Morton, Randy M Wadkins, Israel Silman, Joel L Sussman, Philip M Potter Chem Biol Interact Dec 2005 (Vol. 157-158, Pages 153-7) MEDLINE \| Related Records
	Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. Sonal P Sanghani, Sara K Quinney, Tyler B Fredenburg, Zejin Sun, Wilhelmina I Davis, Daryl J Murry, Oscar W Cummings, David E Seitz, William F Bosron Clin Cancer Res Oct 2003 (Vol. 9, Issue 13, Pages 4983-91) MEDLINE \| Related Records
	Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase. T Satoh, M Hosokawa, R Atsumi, W Suzuki, H Hakusui, E Nagai Biol Pharm Bull May 1994 (Vol. 17, Issue 5, Pages 662-4) MEDLINE \| Related Records

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