Journal of Allergy and Clinical Immunology

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The changes in the T helper 1 (Th1) and T helper 2 (Th2) cytokine balance during HIV-1 infection are indicative of an allergic response to viral proteins that may be reversed by Th2 cytokine inhibitors and immune response modifiers--a review and hypothesis.
Yechiel Becker
Virus Genes
Jan 2004 (Vol. 28, Issue 1, Pages 5-18)
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	Generation of Th1 immune responses to inactivated, gp120-depleted HIV-1 in mice with a dominant Th2 biased immune profile via immunostimulatory [correction of imunostimulatory] oligonucleotides--relevance to AIDS vaccines in developing countries. Mila Ayash-Rashkovsky, Ziva Weisman, Jocelyn Diveley, Ronald B Moss, Zvi Bentwich, Gadi Borkow Vaccine Jun 2002 (Vol. 20, Issue 21-22, Pages 2684-92) MEDLINE \| Related Records
	Notch ligand mRNA levels of human APCs predict Th1/Th2-promoting activities. Masatoshi Wakui, Kazuhisa Nakano, Sho Matsushita Biochem Biophys Res Commun Jun 2007 (Vol. 358, Issue 2, Pages 596-601) MEDLINE \| Related Records
	rOv-ASP-1, a recombinant secreted protein of the helminth Onchocercavolvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens. Angus J MacDonald, Long Cao, Yuxian He, Qian Zhao, Shibo Jiang, Sara Lustigman Vaccine May 2005 (Vol. 23, Issue 26, Pages 3446-52) MEDLINE \| Related Records
	Inulin-derived adjuvants efficiently promote both Th1 and Th2 immune responses. Diego G Silva, Peter D Cooper, Nikolai Petrovsky Immunol Cell Biol Dec 2004 (Vol. 82, Issue 6, Pages 611-6) MEDLINE \| Related Records
	Suramin has adjuvant properties and promotes expansion of antigen-specific Th1 and Th2 cells in vivo. Michael Denkinger, Carey L Shive, Birte Pantenburg, Thomas G Forsthuber Int Immunopharmacol Jan 2004 (Vol. 4, Issue 1, Pages 15-24) MEDLINE \| Related Records
	Effectiveness of intranasal immunization with HIV-gp160 and an HIV-1 env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G). C B Morris, E Cheng, A Thanawastien, L Cárdenas-Freytag, J D Clements Vaccine Mar 2000 (Vol. 18, Issue 18, Pages 1944-51) MEDLINE \| Related Records
	Vaccine-induced Th1-type responses are dominant over Th2-type responses in the short term whereas pre-existing Th2 responses are dominant in the longer term. G J Fernando, T J Stewart, R W Tindle, I H Frazer Scand J Immunol May 1998 (Vol. 47, Issue 5, Pages 459-65) MEDLINE \| Related Records
	The adjuvant combination monophosphoryl lipid A and QS21 switches T cell responses induced with a soluble recombinant HIV protein from Th2 to Th1. A Moore, L McCarthy, K H Mills Vaccine Jun 1999 (Vol. 17, Issue 20-21, Pages 2517-27) MEDLINE \| Related Records
	Cytokine adjuvants: lessons from the past--guidelines for the future? H P Hughes Vet Immunol Immunopathol May 1998 (Vol. 63, Issue 1-2, Pages 131-8) MEDLINE \| Related Records
	Novel aggregate structure adjuvants modulate lymphocyte proliferation and Th1 and Th2 cytokine profiles in ovalbumin immunized mice. P Rajananthanan, G S Attard, N A Sheikh, W J Morrow Vaccine Aug 1999 (Vol. 18, Issue 1-2, Pages 140-52) MEDLINE \| Related Records
	Adjuvants in perspective. F R Vogel Dev Biol Stand 1998 (Vol. 92, Pages 241-8) MEDLINE \| Related Records
	Th1 adjuvant N-acetyl-D-glucosamine polymer up-regulates Th1 immunity but down-regulates Th2 immunity against a mycobacterial protein (MPB-59) in interleukin-10-knockout and wild-type mice. Y Shibata, I Honda, J P Justice, M R Van Scott, R M Nakamura, Q N Myrvik Infect Immun Oct 2001 (Vol. 69, Issue 10, Pages 6123-30) MEDLINE \| Related Records
	A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria-tetanus-pertussis vaccine. Toshiyuki Sugai, Masaaki Mori, Masatoshi Nakazawa, Motohide Ichino, Takuya Naruto, Naoki Kobayashi, Yoshinori Kobayashi, Mutsuhiko Minami, Shumpei Yokota Vaccine Nov 2005 (Vol. 23, Issue 46-47, Pages 5450-6) MEDLINE \| Related Records
	Influence of aluminum-based adjuvant on the immune response to multiantigenic formulation. Enrique Iglesias, Orisley Franch, Yamilka Carrazana, Yadira Lobaina, Daymir García, Jorge Sanchez, José García, Dioslaida Urquiza, Verena Muzio, Gerardo Guillén, Julio C Aguilar Viral Immunol 2006 (Vol. 19, Issue 4, Pages 712-21) MEDLINE \| Related Records
	Pathways for potentiation of immunogenicity during adjuvant-assisted immunizations with Plasmodium falciparum major merozoite surface protein 1. G S Hui, C N Hashimoto Infect Immun Nov 1998 (Vol. 66, Issue 11, Pages 5329-36) MEDLINE \| Related Records
	Immunity in neonates. Bror Morein, Izzeldin Abusugra, Gunilla Blomqvist Vet Immunol Immunopathol Sep 2002 (Vol. 87, Issue 3-4, Pages 207-13) MEDLINE \| Related Records
	Effects of the nature of adjuvant and site of parenteral immunization on the serum and mucosal immune responses induced by a nasal boost with a vaccine alone. B Guy, S Fourage, C Hessler, V Sanchez, M J Millet Clin Diagn Lab Immunol Sep 1998 (Vol. 5, Issue 5, Pages 732-6) MEDLINE \| Related Records
	Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity. Nikolai Petrovsky Vaccine Apr 2006 (Vol. 24 Suppl 2, Pages S2-9) MEDLINE \| Related Records
	Immunostimulatory CpG motifs induce CTL responses to HIV type I oligomeric gp140 envelope protein. Mangala Rao, Gary R Matyas, Thomas C Vancott, Deborah L Birx, Carl R Alving Immunol Cell Biol Oct 2004 (Vol. 82, Issue 5, Pages 523-30) MEDLINE \| Related Records
	Heat-killed Listeria monocytogenes as an adjuvant converts established murine Th2-dominated immune responses into Th1-dominated responses. V P Yeung, R S Gieni, D T Umetsu, R H DeKruyff J Immunol Oct 1998 (Vol. 161, Issue 8, Pages 4146-52) MEDLINE \| Related Records

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