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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome
DOI: 10.1016/j.jaci.2012.02.054
Background: Mutations in the SP110 gene result in infantile onset of the autosomal recessive primary immunodeficiency disease veno-occlusive disease with immunodeficiency syndrome (VODI), which is cha...
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Simon T. Cliffe,
Donald B. Bloch,
Santi Suryani,
Erik-Jan Kamsteeg,
Danielle T. Avery,
Umaimainthan Palendira,
Joseph A. Church,
Brynn K. Wainstein,
Antonino Trizzino,
Gérard Lefranc,
Carlo Akatcherian,
André Megarbané,
Christian Gilissen,
Despina Moshous,
Janine Reichenbach,
Siraj Misbah,
Uli Salzer,
Mario Abinun,
Peck Y. Ong,
Polina Stepensky,
Ezia Ruga,
John B. Ziegler,
Melanie Wong,
Stuart G. Tangye,
Robert Lindeman,
Michael F. Buckley,
Tony Roscioli
et al.
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Full-length article
(In Press Corrected Proof)
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23 May 2012 |
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The effect of parental allergy on childhood allergic diseases depends on the sex of the child
DOI: 10.1016/j.jaci.2012.03.042
Background: The parent-of-origin effect is important in understanding the genetic basis of childhood allergic diseases and improving our ability to identify high-risk children. Objective: We sought to...
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S. Hasan Arshad,
Wilfried Karmaus,
Abid Raza,
Ramesh J. Kurukulaaratchy,
Sharon M. Matthews,
John W. Holloway,
Alireza Sadeghnejad,
Hongmei Zhang,
Graham Roberts,
Susan L. Ewart
et al.
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Full-length article
(In Press Corrected Proof)
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21 May 2012 |
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Mast cells and IgE activation do not alter the development of oral tolerance in a murine model
DOI: 10.1016/j.jaci.2012.04.011
Background: In addition to their well-known role as potent effector cells in patients with allergic disease, mast cells have important immunomodulatory roles regulating tolerance in allograft rejectio...
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Matthew C. Tunis,
Wojciech Dawicki,
Kaitlyn R. Carson,
Jun Wang,
Jean S. Marshall
et al.
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Full-length article
(In Press Corrected Proof)
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21 May 2012 |
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Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects
DOI: 10.1016/j.jaci.2012.03.045
Background: Genetic variants that contribute to asthma susceptibility might be present at varying frequencies in different populations, which is an important consideration and advantage for performing...
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Dara G. Torgerson,
Daniel Capurso,
Elizabeth J. Ampleford,
Xingnan Li,
Wendy C. Moore,
Christopher R. Gignoux,
Donglei Hu,
Celeste Eng,
Rasika A. Mathias,
William W. Busse,
Mario Castro,
Serpil C. Erzurum,
Anne M. Fitzpatrick,
Benjamin Gaston,
Elliot Israel,
Nizar N. Jarjour,
W. Gerald Teague,
Sally E. Wenzel,
José R. Rodríguez-Santana,
William Rodríguez-Cintrón,
Pedro C. Avila,
Jean G. Ford,
Kathleen C. Barnes,
Esteban G. Burchard,
Timothy D. Howard,
Eugene R. Bleecker,
Deborah A. Meyers,
Nancy J. Cox,
Carole Ober,
Dan L. Nicolae
et al.
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Full-length article
(In Press Corrected Proof)
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21 May 2012 |
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Helminth infection is associated with decreased basophil responsiveness in humans
DOI: 10.1016/j.jaci.2012.04.017
Helminth infections and allergic diseases are characterized by increases in IgE and type 2 cytokines such as IL-4. Despite their common immunopathogenesis, epidemiologic studies reveal an inverse rela...
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David Larson,
Philip J. Cooper,
Marc P. Hübner,
Jorge Reyes,
Maritza Vaca,
Martha Chico,
Heidi H. Kong,
Edward Mitre
et al.
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Short communication
(In Press Corrected Proof)
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18 May 2012 |
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Adult-onset systemic mastocytosis in monozygotic twins with KIT D816V and JAK2 V617F mutations
DOI: 10.1016/j.jaci.2012.04.013
We present clinical, histopathologic, and mutational findings and clinical course over 30 years in a pair of monozygotic twins with adult-onset systemic mastocytosis (SM) both carrying a somatic KIT D...
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Sigurd Broesby-Olsen,
Thomas Kielsgaard Kristensen,
Michael Boe Møller,
Carsten Bindslev-Jensen,
Hanne Vestergaard,
Mastocytosis Centre, Odense University Hospital (MastOUH)
et al.
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Short communication
(In Press Corrected Proof)
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18 May 2012 |
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Caring for the smoking asthmatic patient
DOI: 10.1016/j.jaci.2012.04.015
The asthmatic patient who smokes can represent a distinct disease entity in which a combination of asthma and chronic obstructive pulmonary disease–like phenotypes are blended to a variable degree. Ap...
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Riccardo Polosa,
Pasquale Caponnetto,
Mark F. Sands
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Editorial
(In Press Corrected Proof)
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18 May 2012 |
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Aspergillus species recombinant antigens for serodiagnosis of farmer's lung disease
DOI: 10.1016/j.jaci.2012.03.039
Farmer's lung disease (FLD) is the most frequent occupational hypersensitivity pneumonitis. In the East of France and Finland, various genera of mold (Aspergillus, Absidia = Lichtheimia, and Wallemia)...
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Laurence Millon,
Sandrine Roussel,
Benedicte Rognon,
Manfredo Quadroni,
Karin Salamin,
Gabriel Reboux,
Coralie Barrera,
Jean-Marc Fellrath,
John D. Aubert,
Jean-Charles Dalphin,
Michel Monod
et al.
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Short communication
(In Press Corrected Proof)
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18 May 2012 |
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Corticosteroid use and bone mineral accretion in children with asthma: Effect modification by vitamin D
DOI: 10.1016/j.jaci.2012.04.005
Background: The adverse effects of corticosteroids on bone mineral accretion (BMA) have been well documented. Vitamin D insufficiency, a prevalent condition in the pediatric population, has also been ...
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Sze Man Tse,
H. William Kelly,
Augusto A. Litonjua,
Mark L. Van Natta,
Scott T. Weiss,
Kelan G. Tantisira,
Childhood Asthma Management Program Research Group
et al.
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Full-length article
(In Press Corrected Proof)
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18 May 2012 |
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Adverse reactions to vaccines practice parameter 2012 update
DOI: 10.1016/j.jaci.2012.04.003
These parameters were developed by the Joint Task Force on Practice Parameters (JTFPP), representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the American College of Allergy, ...
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John M. Kelso,
Matthew J. Greenhawt,
James T. Li,
Richard A. Nicklas,
David I. Bernstein,
Joann Blessing-Moore,
Linda Cox,
David Khan,
David M. Lang,
John Oppenheimer,
Jay M. Portnoy,
Christopher R. Randolph,
Diane E. Schuller,
Sheldon L. Spector,
Stephen A. Tilles,
Dana Wallace
et al.
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Full-length article
(In Press Corrected Proof)
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18 May 2012 |
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Parasites and allergic disease: Another piece of the puzzle
DOI: 10.1016/j.jaci.2012.04.012
Immunity to parasitic infections principally involves innate and adaptive TH2 responses and is accompanied by the development of IgE antibodies to parasite antigens. Epidemiologic and experimental stu...
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Robert K. Bush
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Editorial
(In Press Corrected Proof)
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14 May 2012 |
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Delayed-onset adenosine deaminase deficiency: Strategies for an early diagnosis
DOI: 10.1016/j.jaci.2012.04.004
Adenosine deaminase (ADA) deficiency is a well-known cause for severe combined immunodeficiency (SCID). However, hypomorphic mutations in the ADA gene can lead to a different immunodeficiency with var...
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Carsten Speckmann,
Carla Neumann,
Stephan Borte,
Giancarlo la Marca,
Jörn Oliver Sass,
Elisabeth Wiech,
Paul Fisch,
Klaus Schwarz,
Bernd Buchholz,
Michael Schlesier,
Kerstin Felgentreff,
Bodo Grimbacher,
Ines Santisteban,
Pawan Bali,
Michael S. Hershfield,
Stephan Ehl
et al.
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Short communication
(In Press Corrected Proof)
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14 May 2012 |
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Allergen specificity of IgG4-expressing B cells in patients with grass pollen allergy undergoing immunotherapy
DOI: 10.1016/j.jaci.2012.04.006
Background: Serum IgG4 responses to allergen immunotherapy are well documented as blocking allergen binding to receptor-bound IgE on antigen-presenting cells and effector cells, but the molecular char...
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Louisa K. James,
Holly Bowen,
Rosaleen A. Calvert,
Tihomir S. Dodev,
Mohamed H. Shamji,
Andrew J. Beavil,
James M. McDonnell,
Stephen R. Durham,
Hannah J. Gould
et al.
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Full-length article
(In Press Corrected Proof)
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14 May 2012 |
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T- and B-cell defects in a novel purine nucleoside phosphorylase mutation
DOI: 10.1016/j.jaci.2012.03.038
Two autosomal recessive genetic disorders of the purine salvage pathway, including adenosine deaminase and purine nucleoside phosphorylase (PNP) deficiencies, are associated with immunodeficiency. In ...
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Raz Somech,
Atar Lev,
Amos J. Simon,
Suhair Hanna,
Amos Etzioni
et al.
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Short communication
(In Press Corrected Proof)
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14 May 2012 |
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Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo
DOI: 10.1016/j.jaci.2012.04.002
Background: Airway mucus hypersecretion is a key pathophysiologic feature in a number of lung diseases. Cigarette smoke/nicotine and allergens are strong stimulators of airway mucus; however, the mech...
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Sravanthi Gundavarapu,
Julie A. Wilder,
Neerad C. Mishra,
Jules Rir-sima-ah,
Raymond J. Langley,
Shashi P. Singh,
Ali Imran Saeed,
Richard J. Jaramillo,
Katherine M. Gott,
Juan Carlos Peña-Philippides,
Kevin S. Harrod,
J. Michael McIntosh,
Shilpa Buch,
Mohan L. Sopori
et al.
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Full-length article
(In Press Corrected Proof)
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11 May 2012 |
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Intravenous immunoglobulin attenuates airway inflammation through induction of forkhead box protein 3–positive regulatory T cells
DOI: 10.1016/j.jaci.2012.02.050
Background: Intravenous immunoglobulin (IVIG) is a frequently used disease-modifying therapy for a large spectrum of autoimmune and inflammatory conditions, yet its mechanisms of action are incomplete...
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Amir H. Massoud,
Julie Guay,
Karim H. Shalaby,
Eva Bjur,
Aidan Ablona,
Daniel Chan,
Yasaman Nouhi,
Christine T. McCusker,
M. Walid Mourad,
Ciriaco A. Piccirillo,
Bruce D. Mazer
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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Modulation of FcεRI-dependent mast cell response by OX40L via Fyn, PI3K, and RhoA
DOI: 10.1016/j.jaci.2012.03.032
Background: The interaction of mast cells (MCs) with regulatory T cells through the OX40 ligand (OX40L):OX40 axis downregulates FcεRI-dependent immediate hypersensitivity responses both in vitro and i...
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Riccardo Sibilano,
Barbara Frossi,
Ryo Suzuki,
Federica D'Incà,
Giorgia Gri,
Silvia Piconese,
Mario P. Colombo,
Juan Rivera,
Carlo E. Pucillo
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus
DOI: 10.1016/j.jaci.2012.03.040
Background: The relevance of allergic sensitization, as judged by titers of serum IgE antibodies, to the risk of an asthma exacerbation caused by rhinovirus is unclear. Objective: We sought to examine...
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Manuel Soto-Quiros,
Lydiana Avila,
Thomas A.E. Platts-Mills,
John F. Hunt,
Dean D. Erdman,
Holliday Carper,
Deborah D. Murphy,
Silvia Odio,
Hayley R. James,
James T. Patrie,
William Hunt,
Ashli K. O'Rourke,
Michael D. Davis,
John W. Steinke,
Xiaoyan Lu,
Joshua Kennedy,
Peter W. Heymann
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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African ancestry and lung function in Puerto Rican children
DOI: 10.1016/j.jaci.2012.03.035
Background: Puerto Rican and African American subjects share a significant proportion of African ancestry. Recent findings suggest that African ancestry influences lung function in African American ad...
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John M. Brehm,
Edna Acosta-Pérez,
Lambertus Klei,
Kathryn Roeder,
Michael M. Barmada,
Nadia Boutaoui,
Erick Forno,
Michelle M. Cloutier,
Soma Datta,
Roxanne Kelly,
Kathryn Paul,
Jody Sylvia,
Deanna Calvert,
Sherell Thornton-Thompson,
Dorothy Wakefield,
Augusto A. Litonjua,
María Alvarez,
Angel Colón-Semidey,
Glorisa Canino,
Juan C. Celedón
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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Ascaris sensitization is associated with aeroallergen sensitization and airway hyperresponsiveness but not allergic disease in urban Africa
DOI: 10.1016/j.jaci.2012.03.033
Conflicting reports have been published on the association between ascaris sensitization and sensitization to aeroallergens, airway hyperresponsiveness (AHR), and allergic diseases such as asthma, rhi...
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Michael Levin,
Rudzani Muloiwa,
Peter Le Souëf,
Cassim Motala
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Short communication
(In Press Corrected Proof)
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04 May 2012 |
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In moderate-to-severe asthma patients monitoring exhaled nitric oxide during exacerbation is not a good predictor of spirometric response to oral corticosteroid
DOI: 10.1016/j.jaci.2012.03.036
Background: The importance of monitoring exhaled nitric oxide (NO) in asthma remains controversial. Objective: To measure exhaled NO, postnebulized albuterol/ipratropium spirometry, and Asthma Control...
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Arthur F. Gelb,
Roxanna Moridzadeh,
Deepak H. Singh,
Christine Fraser,
Steven C. George
et al.
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Full-length article
(In Press Corrected Proof)
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04 May 2012 |
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Genome-wide association study of the age of onset of childhood asthma
DOI: 10.1016/j.jaci.2012.03.020
Background: Childhood asthma is a complex disease with known heritability and phenotypic diversity. Although an earlier onset has been associated with more severe disease, there has been no genome-wid...
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Erick Forno,
Jessica Lasky-Su,
Blanca Himes,
Judie Howrylak,
Clare Ramsey,
John Brehm,
Barbara Klanderman,
John Ziniti,
Erik Melén,
Goran Pershagen,
Magnus Wickman,
Fernando Martinez,
Dave Mauger,
Christine Sorkness,
Kelan Tantisira,
Benjamin A. Raby,
Scott T. Weiss,
Juan C. Celedón
et al.
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Full-length article
(In Press Corrected Proof)
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04 May 2012 |
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Aspirin as a cause of pancreatitis in patients with aspirin-exacerbated respiratory disease
DOI: 10.1016/j.jaci.2012.04.016
Hoyte et al presented 3 cases of acute pancreatitis appearing in patients with aspirin-exacerbated respiratory disease (AERD) who recently underwent aspirin challenge/desensitization. The editors of t...
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Donald D. Stevenson,
Andrew A. White,
Ronald A. Simon
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Editorial
(In Press Corrected Proof)
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03 May 2012 |
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Responses to ragweed pollen in a pollen challenge chamber versus seasonal exposure identifies allergic rhinoconjunctivitis endotypes
DOI: 10.1016/j.jaci.2012.03.031
Background: The level of concordance between allergic symptoms induced on exposure to pollen in a pollen challenge chamber (PCC) versus the natural season is unknown. Objective: We sought to test the ...
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Robert L. Jacobs,
Nathan Harper,
Weijing He,
Charles P. Andrews,
Cynthia G. Rather,
Daniel A. Ramirez,
Sunil K. Ahuja
et al.
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Full-length article
(In Press Corrected Proof)
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03 May 2012 |
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Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa
DOI: 10.1016/j.jaci.2012.04.009
Background: Oral immunotherapy (OIT) is a promising treatment for food allergy. Studies are needed to elucidate mechanisms of clinical protection and to identify safer and potentially more efficacious...
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Stephanie A. Leonard,
Gustavo Martos,
Wei Wang,
Anna Nowak-Węgrzyn,
M. Cecilia Berin
et al.
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Full-length article
(In Press Corrected Proof)
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03 May 2012 |
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TH17 deficiency in human disease
DOI: 10.1016/j.jaci.2012.03.034
The differentiation of naive T cells into distinct subsets of effector T cells is critical for effective immunity against a wide variety of infectious agents in the environment. Activation of innate i...
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Douglas R. McDonald
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Review article
(In Press Corrected Proof)
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03 May 2012 |
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The IL6R variation Asp358Ala is a potential modifier of lung function in subjects with asthma
DOI: 10.1016/j.jaci.2012.03.018
Background: The IL6R single nucleotide polymorphism (SNP) rs4129267 has recently been identified as an asthma susceptibility locus in subjects of European ancestry but has not been characterized with ...
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Gregory A. Hawkins,
Mac B. Robinson,
Annette T. Hastie,
Xingnan Li,
Huashi Li,
Wendy C. Moore,
Timothy D. Howard,
William W. Busse,
Serpil C. Erzurum,
Sally E. Wenzel,
Stephen P. Peters,
Deborah A. Meyers,
Eugene R. Bleecker,
National Heart, Lung, and Blood Institute–sponsored Severe Asthma Research Program (SARP)
et al.
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Full-length article
(In Press Corrected Proof)
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03 May 2012 |
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Over- and underestimated parameters in severe Hymenoptera venom–induced anaphylaxis: Cardiovascular medication and absence of urticaria/angioedema
DOI: 10.1016/j.jaci.2012.03.024
Background: Severe anaphylaxis in Hymenoptera venom allergy has been associated with a number of risk factors including elevation of baseline serum tryptase (BST), older age, concomitant diseases, and...
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Johanna Stoevesandt,
Johannes Hain,
Andreas Kerstan,
Axel Trautmann
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Full-length article
(In Press Corrected Proof)
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03 May 2012 |
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Accurate oral food challenge requires a cumulative dose on a subsequent day
DOI: 10.1016/j.jaci.2012.03.021
Food allergy remains a major problem, not only in terms of an accurate diagnosis to determine the clinically relevant allergen but also to avoid unnecessary or even harmful elimination diets. Oral foo...
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Bodo Niggemann,
Lars Lange,
Antje Finger,
Mandy Ziegert,
Veronika Müller,
Kirsten Beyer
et al.
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Short communication
(In Press Corrected Proof)
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02 May 2012 |
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Ovomucoids IgE is a better marker than egg white–specific IgE to diagnose boiled egg allergy
DOI: 10.1016/j.jaci.2012.03.041
The oral food challenge (OFC) is the most reliable method to confirm a primary food allergy diagnosis. However, because of the risk of severe allergic reactions during the OFC, physicians are interest...
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Yasuhiro Haneda,
Naoyuki Kando,
Masahiro Yasui,
Takae Kobayashi,
Toru Maeda,
Asuka Hino,
Shunji Hasegawa,
Takashi Ichiyama,
Komei Ito
et al.
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Short communication
(In Press Corrected Proof)
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02 May 2012 |
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Allergic airway disease is unaffected by the absence of IL-4Rα–dependent alternatively activated macrophages
DOI: 10.1016/j.jaci.2012.03.011
Background: Markers of alternatively activated macrophages (AAMs) are upregulated in the lungs of asthmatic patients and in mice with allergic airway disease. AAMs are thought to contribute to the pat...
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Natalie E. Nieuwenhuizen,
Frank Kirstein,
Jaisubash Jayakumar,
Babele Emedi,
Ramona Hurdayal,
William G.C. Horsnell,
Andreas L. Lopata,
Frank Brombacher
et al.
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Full-length article
(In Press Corrected Proof)
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02 May 2012 |
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Effect of secondhand smoke on asthma control among black and Latino children
DOI: 10.1016/j.jaci.2012.03.017
Background: Among patients with asthma, the clinical effect and relative contribution of maternal smoking during pregnancy (in utero smoking) and current secondhand smoke (SHS) exposure on asthma cont...
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Sam S. Oh,
Haig Tcheurekdjian,
Lindsey A. Roth,
Elizabeth A. Nguyen,
Saunak Sen,
Joshua M. Galanter,
Adam Davis,
Harold J. Farber,
Frank D. Gilliland,
Rajesh Kumar,
Pedro C. Avila,
Emerita Brigino-Buenaventura,
Rocio Chapela,
Jean G. Ford,
Michael A. LeNoir,
Fred Lurmann,
Kelley Meade,
Denise Serebrisky,
Shannon Thyne,
William Rodriguez-Cintron,
Jose R. Rodriguez-Santana,
L. Keoki Williams,
Luisa N. Borrell,
Esteban G. Burchard
et al.
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Full-length article
(In Press Corrected Proof)
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02 May 2012 |
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Inhibitory human antichimeric antibodies to rituximab in a patient with pemphigus
DOI: 10.1016/j.jaci.2012.03.022
Rituximab is a chimeric mouse-human IgG1 mAb that targets CD20, a transmembrane protein expressed on B cells. It has demonstrated success in 2 prospective case series in pemphigus, a potentially fatal...
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Luisa Lunardon,
Aimee S. Payne
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Short communication
(In Press Corrected Proof)
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30 April 2012 |
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IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti–IL-4 receptor α antagonist
DOI: 10.1016/j.jaci.2012.03.030
Background: This is the first large pharmacogenetic investigation of the inflammatory IL-4/IL-13 pathway in patients with moderate-to-severe asthma. We analyzed genomic DNA from participants in a 12-w...
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Rebecca E. Slager,
Babatunde A. Otulana,
Gregory A. Hawkins,
Yu Ping Yen,
Stephen P. Peters,
Sally E. Wenzel,
Deborah A. Meyers,
Eugene R. Bleecker
et al.
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Full-length article
(In Press Corrected Proof)
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30 April 2012 |
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A self-regulation intervention can improve quality of life for families with food allergy
DOI: 10.1016/j.jaci.2012.03.029
Food allergy (FA) affects 3.9% to 8% of children. Children with FA and families have a lower quality of life (QoL) and might have maladaptive coping strategies. Such psychological aspects of living wi...
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Alan P. Baptist,
Sara I. Dever,
Matthew J. Greenhawt,
Nancy Polmear-Swendris,
Marc S. McMorris,
Noreen M. Clark
et al.
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Short communication
(In Press Corrected Proof)
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30 April 2012 |
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Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis
DOI: 10.1016/j.jaci.2012.03.023
Background: Eosinophilic esophagitis is a chronic, immune-mediated inflammatory disorder that responds to dietary therapy; however, data evaluating the effectiveness of dietary therapeutic strategies ...
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Carol J. Henderson,
J. Pablo Abonia,
Eileen C. King,
Philip E. Putnam,
Margaret H. Collins,
James P. Franciosi,
Marc E. Rothenberg
et al.
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Full-length article
(In Press Corrected Proof)
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30 April 2012 |
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Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization
DOI: 10.1016/j.jaci.2012.02.045
Background: The extensive similarities between helminth proteins and allergens are thought to contribute to helminth-driven allergic sensitization. Objective: The objective of this study was to invest...
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Helton C. Santiago,
Elyse LeeVan,
Sasisekhar Bennuru,
Flavia Ribeiro-Gomes,
Ellen Mueller,
Mark Wilson,
Thomas Wynn,
David Garboczi,
Joseph Urban,
Edward Mitre,
Thomas B. Nutman
et al.
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Full-length article
(In Press Corrected Proof)
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27 April 2012 |
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Long-term safety and asthma control measures with a budesonide/formoterol pressurized metered-dose inhaler in African American asthmatic patients: A randomized controlled trial
DOI: 10.1016/j.jaci.2012.03.028
Background: Information surrounding the long-term safety of combination inhaled corticosteroid/long-acting β2-adrenergic agonist medications in African American asthmatic patients is limited. Objectiv...
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Randall W. Brown,
Christopher D. O'Brien,
Ubaldo J. Martin,
Tom Uryniak,
Kathy L. Lampl
et al.
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Full-length article
(In Press Corrected Proof)
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27 April 2012 |
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Amplification of Toll-like receptor–mediated signaling through spleen tyrosine kinase in human B-cell activation
DOI: 10.1016/j.jaci.2012.03.014
Background: B cells are activated by combined signals through the B-cell receptor (BCR) and CD40. However, the underlying mechanisms by which BCR signals synergize with Toll-like receptor (TLR) signal...
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Shigeru Iwata,
Kunihiro Yamaoka,
Hiroaki Niiro,
Kazuhisa Nakano,
Sheau-Pey Wang,
Koichi Akashi,
Yoshiya Tanaka
et al.
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Full-length article
(In Press Corrected Proof)
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27 April 2012 |
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Promoter polymorphisms in CHI3L1 are associated with asthma
DOI: 10.1016/j.jaci.2012.03.015
Increased expression of the glycoprotein Chitinase-3-like-1 (CHI3L1) gene has been associated with cancers, autoimmune diseases, and chronic inflammatory conditions such as asthma (reviewed in Coffman...
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Dominique J. Verlaan,
Manon Ouimet,
Veronique Adoue,
Dave Sirois-Gagnon,
Mathieu Larivière,
Bing Ge,
Patrick Beaulieu,
Joana Dias,
Kevin C.L. Lam,
Vonda Koka,
Catherine Laprise,
Tomi Pastinen,
Daniel Sinnett
et al.
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Short communication
(In Press Corrected Proof)
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25 April 2012 |
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STAT6 and LRP1 polymorphisms are associated with food allergen sensitization in Mexican children
DOI: 10.1016/j.jaci.2012.03.012
Food allergy, affecting up to 8% of children in the United States, is most often mediated by allergen-specific IgE antibodies in the blood. Food allergen sensitization is an intermediate phenotype mea...
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Dana B. Hancock,
Isabelle Romieu,
Grace Y. Chiu,
Juan-Jose Sienra-Monge,
Huiling Li,
Blanca Estela del Rio-Navarro,
Stephanie J. London
et al.
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Short communication
(In Press Corrected Proof)
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25 April 2012 |
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Protection from childhood asthma and allergy in Alpine farm environments—the GABRIEL Advanced Studies
DOI: 10.1016/j.jaci.2012.03.013
Background: Studies on the association of farm environments with asthma and atopy have repeatedly observed a protective effect of farming. However, no single specific farm-related exposure explaining ...
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Sabina Illi,
Martin Depner,
Jon Genuneit,
Elisabeth Horak,
Georg Loss,
Christine Strunz-Lehner,
Gisela Büchele,
Andrzej Boznanski,
Hanna Danielewicz,
Paul Cullinan,
Dick Heederik,
Charlotte Braun-Fahrländer,
Erika von Mutius,
GABRIELA Study Group
et al.
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Full-length article
(In Press Corrected Proof)
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25 April 2012 |
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Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps
DOI: 10.1016/j.jaci.2012.02.046
Background: Although chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is characterized by TH2 inflammation, the role of mast cells is poorly understood. Objective: The objective of this study w...
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Tetsuji Takabayashi,
Atsushi Kato,
Anju T. Peters,
Lydia A. Suh,
Roderick Carter,
James Norton,
Leslie C. Grammer,
Bruce K. Tan,
Rakesh K. Chandra,
David B. Conley,
Robert C. Kern,
Shigeharu Fujieda,
Robert P. Schleimer
et al.
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Full-length article
(In Press Corrected Proof)
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25 April 2012 |
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The effect of montelukast, budesonide alone, and in combination on exercise-induced bronchoconstriction
DOI: 10.1016/j.jaci.2012.02.051
Current guidelines recommend regular inhaled corticosteroids (ICS) or alternatively cysteinyl leukotriene (CysLT) modifiers for the treatment of asthma. The CysLT pathway has been shown to be importan...
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MyLinh Duong,
Reshma Amin,
Adrian J. Baatjes,
Fiona Kritzinger,
Ying Qi,
Zahida Meghji,
Wendy Lou,
Hartmut Grasemann,
Paul M. O'Byrne,
Padmaja Subbarao
et al.
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Short communication
(In Press Corrected Proof)
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25 April 2012 |
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The public health benefits of air pollution control
DOI: 10.1016/j.jaci.2012.02.047
The US Congress is currently engaged in a debate regarding restriction of Environmental Protection Agency (EPA) authority under the Clean Air Act. The discussion has been focused on the cost to busine...
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Jinghong Li,
Gary Ewart,
Monica Kraft,
Patricia W. Finn
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Editorial
(In Press Corrected Proof)
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23 April 2012 |
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TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis
DOI: 10.1016/j.jaci.2012.03.006
Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disorder characterized by a TH2 environment and epidermal barrier dysfunction. A primary defect in the epidermal barrier has been propose...
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Shin Morizane,
Kenshi Yamasaki,
Ai Kajita,
Kazuko Ikeda,
Maosheng Zhan,
Yumi Aoyama,
Richard L. Gallo,
Keiji Iwatsuki
et al.
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Short communication
(In Press Corrected Proof)
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23 April 2012 |
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Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways
DOI: 10.1016/j.jaci.2012.02.042
Background: Newborns have frequent infections and manifest impaired vaccine responses, motivating a search for neonatal vaccine adjuvants. Alum is a neonatal adjuvant but might confer a TH2 bias. Toll...
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Victoria J. Philbin,
David J. Dowling,
Leighanne C. Gallington,
Guadalupe Cortés,
Zhen Tan,
Eugénie E. Suter,
Kevin W. Chi,
Ariel Shuckett,
Liat Stoler-Barak,
Mark Tomai,
Richard L. Miller,
Keith Mansfield,
Ofer Levy
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Development of atopic dermatitis according to age of onset and association with early-life exposures
DOI: 10.1016/j.jaci.2012.02.043
Background: Environmental factors can affect the development of atopic dermatitis, and this was described to be already effective during pregnancy and in early life. An important early postnatal expos...
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Caroline Roduit,
Remo Frei,
Georg Loss,
Gisela Büchele,
Juliane Weber,
Martin Depner,
Susanne Loeliger,
Marie-Laure Dalphin,
Marjut Roponen,
Anne Hyvärinen,
Josef Riedler,
Jean-Charles Dalphin,
Juha Pekkanen,
Erika von Mutius,
Charlotte Braun-Fahrländer,
Roger Lauener,
Protection Against Allergy–Study in Rural Environments study group
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Local allergic rhinitis: Concept, pathophysiology, and management
DOI: 10.1016/j.jaci.2012.02.032
Local allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy characterized by local production of specific IgE (sIgE) antibodies, a TH2 pattern of mucosal cell...
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Carmen Rondón,
Paloma Campo,
Alkis Togias,
Wytske J. Fokkens,
Stephen R. Durham,
Desmond G. Powe,
Joaquim Mullol,
Miguel Blanca
et al.
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Full-length article
(In Press Corrected Proof)
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20 April 2012 |
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Amish children living in Northern Indiana have a very low prevalence of allergic sensitization
DOI: 10.1016/j.jaci.2012.03.016
The prevalence of allergic sensitization has increased in most developed counties over the past century. In the United States, the third National Health and Nutrition Examination Survey found 54.3% of...
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Mark Holbreich,
Jon Genuneit,
Juliane Weber,
Charlotte Braun-Fahrlaender,
Marco Waser,
Erika von Mutius
et al.
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Short communication
(In Press Corrected Proof)
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19 April 2012 |
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Patchy eosinophil distributions in an esophagectomy specimen from a patient with eosinophilic esophagitis: Implications for endoscopic biopsy
DOI: 10.1016/j.jaci.2012.03.009
Eosinophilic esophagitis (EoE) is characterized by patchy infiltration into the esophagus by eosinophils, inflammatory leukocytes not found in the healthy esophagus. The pathologic diagnosis can be di...
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Hedieh Saffari,
Kathryn A. Peterson,
John C. Fang,
Carolin Teman,
Gerald J. Gleich,
Leonard F. Pease
et al.
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Short communication
(In Press Corrected Proof)
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16 April 2012 |
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Novel severe wheezy young children phenotypes: Boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze
DOI: 10.1016/j.jaci.2012.02.041
Background: Recurrent wheezing during infancy is a heterogeneous disorder that has been associated with early-onset asthma. Objective: To identify phenotypes of severe recurrent wheezing and therapeut...
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Jocelyne Just,
Rahele Gouvis-Echraghi,
Remy Couderc,
Nathalie Guillemot-Lambert,
Philippe Saint-Pierre
et al.
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Full-length article
(In Press Corrected Proof)
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16 April 2012 |
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Case-control admixture mapping in Latino populations enriches for known asthma-associated genes
DOI: 10.1016/j.jaci.2012.02.040
Background: Polymorphisms in more than 100 genes have been associated with asthma susceptibility, yet much of the heritability remains to be explained. Asthma disproportionately affects different raci...
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Dara G. Torgerson,
Christopher R. Gignoux,
Joshua M. Galanter,
Katherine A. Drake,
Lindsey A. Roth,
Celeste Eng,
Scott Huntsman,
Raul Torres,
Pedro C. Avila,
Rocio Chapela,
Jean G. Ford,
José R. Rodríguez-Santana,
William Rodríguez-Cintrón,
Ryan D. Hernandez,
Esteban G. Burchard
et al.
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Full-length article
(In Press Corrected Proof)
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16 April 2012 |
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Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function
DOI: 10.1016/j.jaci.2012.03.001
Background: Many immune-mediated diseases are associated with low levels of vitamin D and sunlight. UV light or supplementation with vitamin D can increase regulatory T-cell activity and prevent anima...
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Sarah V.I. Milliken,
Heather Wassall,
Barry J. Lewis,
Judith Logie,
Robert N. Barker,
Helen Macdonald,
Mark A. Vickers,
Anthony D. Ormerod
et al.
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Full-length article
(In Press Corrected Proof)
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16 April 2012 |
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Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)−/− mice
DOI: 10.1016/j.jaci.2012.03.002
Background: Mycoplasma pneumoniae (Mp) frequently colonizes the airways of patients with chronic asthma and likely contributes to asthma exacerbations. We previously reported that mice lacking surfact...
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Bethany J. Hsia,
Julie G. Ledford,
Erin N. Potts-Kant,
Vinayak S. Nikam,
Njira L. Lugogo,
W. Michael Foster,
Monica Kraft,
Soman N. Abraham,
Jo Rae Wright
et al.
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Full-length article
(In Press Corrected Proof)
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16 April 2012 |
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Tolerance induction with T cell–dependent protein antigens induces regulatory sialylated IgGs
DOI: 10.1016/j.jaci.2012.02.037
Background: Under inflammatory conditions, T cell–dependent (TD) protein antigens induce proinflammatory T- and B-cell responses. In contrast, tolerance induction by TD antigens without costimulation ...
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Carolin M. Oefner,
André Winkler,
Constanze Hess,
Alexandra K. Lorenz,
Vivien Holecska,
Melanie Huxdorf,
Tim Schommartz,
Dominique Petzold,
Josephine Bitterling,
Anna-Lena Schoen,
Alexander D. Stoehr,
Dana Vu Van,
Yasemin Darcan-Nikolaisen,
Véronique Blanchard,
Inken Schmudde,
Yves Laumonnier,
Heike A. Ströver,
Ahmed N. Hegazy,
Susanne Eiglmeier,
Carolin T. Schoen,
Maria M.M. Mertes,
Christoph Loddenkemper,
Max Löhning,
Peter König,
Arnd Petersen,
Elke O. Luger,
Mattias Collin,
Jörg Köhl,
Andreas Hutloff,
Eckard Hamelmann,
Markus Berger,
Hedda Wardemann,
Marc Ehlers
et al.
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Full-length article
(In Press Corrected Proof)
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16 April 2012 |
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Does diversity of environmental microbial exposure matter for the occurrence of allergy and asthma?
DOI: 10.1016/j.jaci.2012.01.067
This review describes the recent literature on microbial exposures and protective effects for asthma and atopy. Certain microorganism-associated molecular patterns have been identified as agents that ...
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Dick Heederik,
Erika von Mutius
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Full-length article
(In Press Corrected Proof)
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16 April 2012 |
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Reply
DOI: 10.1016/j.jaci.2012.02.053
We thank Liccardi et al for their comments on our article dealing with new-onset cat sensitization in adults.
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Mario Olivieri,
Deborah Jarvis,
Jan-Paul Zock,
Joachim Heinrich,
Josep M. Antó,
Giuseppe Verlato
et al.
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Correspondence
(In Press Corrected Proof)
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12 April 2012 |
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Is cat-keeping the main determinant of new-onset adulthood cat sensitization?
DOI: 10.1016/j.jaci.2012.02.052
We read with interest the article from Olivieri et al showing that acquiring a cat in adulthood increases the risk of new-onset sensitization to cat allergens. Similar studies had been performed in pe...
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Gennaro Liccardi,
Antonello Salzillo,
Lorenzo Cecchi,
Maria D'Amato,
Gennaro D'Amato
et al.
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Correspondence
(In Press Corrected Proof)
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12 April 2012 |
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Methacholine challenge test: Diagnostic characteristics in asthmatic patients receiving controller medications
DOI: 10.1016/j.jaci.2012.02.025
Background: The methacholine challenge test (MCT) is commonly used to assess airway hyperresponsiveness, but the diagnostic characteristics have not been well studied in asthmatic patients receiving c...
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Kaharu Sumino,
Elizabeth A. Sugar,
Charles G. Irvin,
David A. Kaminsky,
Dave Shade,
Christine Y. Wei,
Janet T. Holbrook,
Robert A. Wise,
Mario Castro,
American Lung Association Asthma Clinical Research Centers
et al.
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Full-length article
(In Press Corrected Proof)
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02 April 2012 |
