Featured Article of the Week
Allergen-specific immunotherapy reduced to 3 injections Allergen-specific immunotherapy is the only disease-modifying treatment of allergies, but it requires numerous allergen administrations over 3 to 5 years, so that less than 5% of patients with allergies choose immunotherapy. Senti et al (p 1290) could reduce the number of allergen injections to 3 by enhancing antigen presentation. First, allergen was injected directly into lymph nodes. Second, the allergen, recombinant cat dander allergen Fel d 1, was fused with an intracellular translocation sequence and with an invariant chain to enhance presentation through MHC class II to CD4 T cells.
View all Featured Articles for this month.
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Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome23 May 2012
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The effect of parental allergy on childhood allergic diseases depends on the sex of the child21 May 2012
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Mast cells and IgE activation do not alter the development of oral tolerance in a murine model21 May 2012
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Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects21 May 2012
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Helminth infection is associated with decreased basophil responsiveness in humans18 May 2012
Special Features
Shared Science. In collaboration with other journals and their sponsoring societies, the JACI is pleased to offer free online access to selected articles.
JACI in the News. View coverage of JACI articles in news outlets from around the world.
Advances in Allergy and Immunology. Our annual series reviewing the best and most exciting research reported in JACI during the previous year.
News Beyond Our Pages. Drs. Marc Rothenberg and Jean Bousquet bring you the latest in news, ideas, and research for the allergist-immunologist.
