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Current Issue

November 2009 | Vol. 124, No. 5

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Special Reprint Compilation on Atopic Dermatitis and Skin Biology Now Available:

The Epidermal Skin Barrier: Aspects of Biology and Dysfunction
Free access to these articles is sponsored by Novartis Pharma AG

Featured Article of the Week:


Prenatal and maternal influences on newborn immune responses of US urban children
Immunologic responses at birth likely relate to subsequent risks for allergic diseases and wheezing in infancy, but maternal and prenatal influences on neonatal responses are not well understood. At birth, cord blood mononuclear cells can respond to both innate and adaptive stimuli, although innate responses are more developed. The innate immune system defends the host from infection in a nonspecific manner. The adaptive immune system confers more longlasting protective immunity against infection but also can be involved in allergic responses. Gold et al (p 1078) evaluated the influences of maternal and prenatal factors on cord blood mononuclear cell cytokine production in response to innate and adaptive stimuli in 560 and 49 children from families with and without an allergy/asthma history participating in URECA, a prospective multicenter urban birth cohort study. Responses to stimuli were generally lower to adaptive than innate stimuli and were lower in infants with a parental history of allergy/asthma. Season of birth (see Figure), birth weight, gestational age, and ethnicity influenced the magnitude of the responses. Maternal asthma was associated with reduced cytokine responses to respiratory syncytial virus. Pregnancy, birth, and family characteristics influence immune responses in children at birth. Follow-up of these urban children will help us understand the clinical implications of our findings on allergy and asthma development. Read the full article here.

View all Featured Articles for this month.

Special Features:

Shared Science. In collaboration with other journals and their sponsoring societies, the JACI is pleased to offer free online access to selected articles.
JACI in the News. View coverage of JACI articles in news outlets from around the world.
Presentation Tools. Spice up your presentations with downloadable PowerPoint files and videos containing selected JACI figures.
Article Collections. Browse articles from several of the JACI's ongoing series of review and feature articles.
Most-Accessed Articles. What JACI articles are other people interested in? View the latest list of most-accessed articles from the past few months.
Advances in Allergy and Immunology. Our annual series reviewing the best and most exciting research reported in JACI during the previous year.
News Beyond Our Pages. Drs. Marc Rothenberg and Harold Nelson bring you the latest in news, ideas, and research for the allergist-immunologist.


The Journal of Allergy and Clinical Immunology is published by Elsevier for the American Academy of Allergy, Asthma & Immunology.

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