| Electronic Images of the Month |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Microcoil Slipping Out of the Gastric Varices
16 December 2011
A 67-year-old man with alcoholic cirrhosis developed a gastric varix with a gastrorenal shunt. He underwent the interventional radiology of balloon-occluded retrograde transvenous obliteration and per...
|
Kosaku Moribata,
Jun Kato,
Masao Ichinose
|
e53
|
|
|
|
Portal Hypertensive Enteropathy in Small-Bowel Capsule Endoscopy
26 December 2011
A 41-year-old woman, with a long history of alcoholic liver disease, underwent a small-bowel capsule endoscopy (SBCE) to investigate her recurrent and severe anemia. Prior bidirectional endoscopy had ...
|
Anastasios Koulaouzidis,
Gillian Ritchie,
John N. Plevris
|
e54-e55
|
|
| CME Activities |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Exam 1: Many Patients Continue Using Proton Pump Inhibitors After Negative Results From Tests for Reflux Disease
12 April 2012
|
C. Mel Wilcox
|
e56-e57
|
|
|
|
Exam 2: Patients Whose First Episode of Bleeding Occurs While Taking a β-Blocker Have High Long-term Risks of Rebleeding and Death
12 April 2012
|
C. Mel Wilcox
|
e58
|
|
| Abstracts From Around the World |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Abstracts from Around the World
16 April 2012
Proton pump inhibitor (PPI) therapy revolutionized management of gastroesophageal reflux disease (GERD). Despite the potency of these agents, there remains a subgroup of patients with reflux-type symp...
|
|
565-567
|
|
| Editorials |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Nonalcoholic Fatty Liver Disease and Cardiovascular Disease Risk
05 March 2012
The metabolic syndrome (MetSyn) is a constellation of cardiovascular risk factors that occur simultaneously in many individuals. The National Cholesterol Education Program Adult Treatment Panel III de...
|
Todd M. Brown
|
568-569
|
|
|
|
Colorectal Cancer Screening: How to Stop a Moving Target
22 March 2012
Population-based colorectal cancer screening by testing for blood in stool with fecal occult blood tests was started around the 1980s. At that time only the so-called guaiac-based fecal occult blood t...
|
Leo G.M. van Rossum
|
570-572
|
|
|
|
So Long, Folks
“It's pretty far, but it doesn't seem like it.” —Yogi Bera
|
C. Mel Wilcox,
Joseph R. Bloomer,
Shyam S. Varadarajulu,
Charles O. Elson
|
573-574
|
|
| Reviews |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Diagnosis and Management of Patients With α1-Antitrypsin (A1AT) Deficiency
26 December 2011
Alpha1-antitrypsin (A1AT) deficiency is an autosomal codominant disease that can cause chronic liver disease, cirrhosis, and hepatocellular carcinoma in children and adults and increases risk for emph...
|
David R. Nelson,
Jeffrey Teckman,
Adrian M. Di Bisceglie,
David A. Brenner
|
575-580
|
|
|
|
Detection, Treatment, and Prevention of Clostridium difficile Infection
19 March 2012
Clostridium difficile is a gram-positive anaerobic bacillus responsible for approximately 1 of 5 cases of antibiotic-associated diarrhea. C difficile infection (CDI) is defined by at least 3 unformed ...
|
David L. McCollum,
J. Martin Rodriguez
|
581-592
|
|
| Education Practice |
| |
Article Title |
Author(s) |
Pages |
|
|
|
A 42–Year–Old Woman With a New Diagnosis of Sclerosing Cholangitis
05 March 2012
A 42-year-old woman is referred to you for severe pruritus, dark urine, and acholic stools. These symptoms have gradually increased during the past 7–10 days. She had previously been in good health wi...
|
Andrea A. Gossard,
Keith D. Lindor
|
593-597
|
|
| Perspective |
| |
Article Title |
Author(s) |
Pages |
|
|
|
The Variable Presentations and Broadening Geographic Distribution of Hepatic Fascioliasis
27 February 2012
We report 2 unrelated cases of hepatic fascioliasis in travelers returning to the United States from Africa and the Middle East. The first case presented with acute infection. Prominent clinical featu...
|
Sarah E. Rowan,
Marilyn E. Levi,
Jean M. Youngwerth,
Brian Brauer,
Gregory T. Everson,
Steven C. Johnson
et al.
|
598-602
|
|
| Endoscopy Corner |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Efficacy of Endoscopic Closure of Acute Perforations of the Gastrointestinal Tract
22 February 2012
Background & Aims: Acute perforations of the gastrointestinal tract are rare, severe complications of endoscopy that usually require surgical repair. Endoscopic repair of perforations would reduce...
|
Rogier P. Voermans,
Olivier Le Moine,
Daniel von Renteln,
Thierry Ponchon,
Marc Giovannini,
Marco Bruno,
Bas Weusten,
Stefan Seewald,
Guido Costamagna,
Pierre Deprez,
Paul Fockens,
CLIPPER Study Group
et al.
|
603-608
|
|
| Practice Management: Opportunities and Challenges |
| |
Article Title |
Author(s) |
Pages |
|
|
|
How May the Transition to Value-Based Payment Influence Gastroenterology: Threat or Opportunity?
Gastroenterology has experienced a surge of innovation and growth over the past decade, with major advances in diagnostic and therapeutic endoscopic procedures and in the basic understanding of diseas...
|
Parambir S. Dulai,
Elliott S. Fisher,
Richard I. Rothstein
|
609-611
|
|
| Original Articles—Alimentary Tract |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Regurgitation Is Less Responsive to Acid Suppression Than Heartburn in Patients With Gastroesophageal Reflux Disease
16 February 2012
Background & Aims: Although most patients with gastroesophageal reflux disease (GERD) achieve substantial symptom relief with acid suppression, many have some residual symptoms. We evaluated the r...
|
Peter J. Kahrilas,
Andreas Jonsson,
Hans Denison,
Börje Wernersson,
Nesta Hughes,
Colin W. Howden
et al.
|
612-619
|
|
|
|
Many Patients Continue Using Proton Pump Inhibitors After Negative Results From Tests for Reflux Disease
23 February 2012
Background & Aims: Ambulatory reflux testing is used to evaluate symptoms of gastroesophageal reflux disease (GERD) refractory to protein pump inhibitors (PPIs). We investigated the prevalence of ...
|
Andrew J. Gawron,
Jami Rothe,
Angela J. Fought,
Anita Fareeduddin,
Erin Toto,
Lubomyr Boris,
Peter J. Kahrilas,
John E. Pandolfino
et al.
|
620-625
|
 
|
|
|
Clinicians Poorly Assess Health Literacy–Related Readiness for Transition to Adult Care in Adolescents With Inflammatory Bowel Disease
05 March 2012
Background & Aims: To prepare for the transition from pediatric to adult-oriented health care systems, adolescents must develop the ability to obtain, process, and understand basic health informat...
|
Jeannie S. Huang,
Allison Tobin,
Trevor Tompane
|
626-632
|
|
|
|
High Rate of Advanced Adenoma Detection in 4 Rounds of Colorectal Cancer Screening With the Fecal Immunochemical Test
19 March 2012
Background & Aims: Few data have been published on the performance of colorectal cancer (CRC) screens that use multiple rounds of the fecal immunochemical test (FIT). We evaluated outcomes of 4 sc...
|
Sergio Crotta,
Nereo Segnan,
Simona Paganin,
Bruna Dagnes,
Roberto Rosset,
Carlo Senore
et al.
|
633-638
|
 
|
|
|
Risk of Colorectal Cancer in Patients With Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies
30 January 2012
Background & Aims: Patients with ulcerative colitis (UC) have an increased risk of developing colorectal cancer (CRC). Studies examining the magnitude of this association have yielded conflicting ...
|
Tine Jess,
Christine Rungoe,
Laurent Peyrin–Biroulet
|
639-645
|
|
| Original Articles—Liver, Pancreas, and Biliary Tract |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Independent Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in the US Population
16 January 2012
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVDs) have common metabolic risk factors. Despite reports from clinical studies, the association between NA...
|
Maria Stepanova,
Zobair M. Younossi
|
646-650
|
|
|
|
Non–High-Density Lipoprotein Cholesterol as a Biomarker for Nonalcoholic Steatohepatitis
13 February 2012
Background & Aims: There are no clinically available biomarkers for nonalcoholic steatohepatitis (NASH); differentiating between steatosis and NASH requires histologic evaluation. Noninvasive meth...
|
Kathleen E. Corey,
Michelle Lai,
Louis G. Gelrud,
Joseph Misdraji,
Lydia L. Barlow,
Hui Zheng,
Karin L. Andersson,
Michael Thiim,
Daniel S. Pratt,
Raymond T. Chung
et al.
|
651-656
|
|
|
|
Liver Biopsy Analysis Has a Low Level of Performance for Diagnosis of Intermediate Stages of Fibrosis
16 February 2012
Background & Aims: There is controversy about the performance of noninvasive tests such as FibroTest in diagnosing intermediate stages of fibrosis. We investigated whether this controversy results...
|
Thierry Poynard,
Gilles Lenaour,
Jean Christophe Vaillant,
Frederique Capron,
Mona Munteanu,
Daniel Eyraud,
Yen Ngo,
Helmi M'Kada,
Vlad Ratziu,
Laurent Hannoun,
Frederic Charlotte
et al.
|
657-663.e7
|
|
|
|
Etiologies and Outcomes of Acute Liver Failure in Germany
27 February 2012
Background & Aims: Acute liver failure (ALF) is a severe form of acute liver injury that can progress to multiple organ failure. We investigated causes and outcomes of ALF. Methods: Eleven univers...
|
Johannes Hadem,
Frank Tacke,
Tony Bruns,
Julia Langgartner,
Pavel Strnad,
Gerald U. Denk,
Panagiotis Fikatas,
Michael P. Manns,
Wolf P. Hofmann,
Guido Gerken,
Frank Grünhage,
Andreas Umgelter,
Christian Trautwein,
Ali Canbay,
Acute Liver Failure Study Group Germany
et al.
|
664-669.e2
|
|
|
|
Patients Whose First Episode of Bleeding Occurs While Taking a β-Blocker Have High Long-term Risks of Rebleeding and Death
23 February 2012
Background & Aims: Patients who have their first episode of variceal bleeding despite primary prophylaxis with a nonselective β-adrenergic receptor antagonist (also called a nonselective β-blocker...
|
Andrea Ribeiro de Souza,
Vincenzo La Mura,
Enric Reverter,
Susana Seijo,
Annalisa Berzigotti,
Eyal Askenazhi,
Juan Carlos García–Pagán,
Juan G. Abraldes,
Jaime Bosch
et al.
|
670-676
|
|
|
|
Effect of Renal Impairment on Mortality of Patients With Cirrhosis and Spontaneous Bacterial Peritonitis
05 March 2012
Background & Aims: The effects of end-stage renal disease (ESRD) on the mortality of patients with cirrhosis and spontaneous bacterial peritonitis (SBP) have not been determined. Methods: We colle...
|
Tsung–Hsing Hung,
Chen–Chi Tsai,
Yu–Hsi Hsieh,
Chih–Chun Tsai,
Chih–Wei Tseng,
Jai–Jen Tsai
et al.
|
677-681
|
|
| Brief Communication |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Patients With Autoimmune Hepatitis Who Have Antimitochondrial Antibodies Need Long-term Follow-up to Detect Late Development of Primary Biliary Cirrhosis
23 February 2012
Patients with autoimmune hepatitis (AIH) who have antibodies against mitochondrial proteins (AMA positive) are believed to have an autoimmune syndrome that should be managed as AIH. Of patients with A...
|
Amreen M. Dinani,
Sandra E. Fischer,
Jeff Mosko,
Maha Guindi,
Gideon M. Hirschfield
et al.
|
682-684
|
|
| Letters to the Editor |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Diabetic Gastroparesis: Myth or Reality?
10 January 2012
We read with interest the article by Parkman et al in which they delineate the similarities and differences between diabetic and idiopathic gastroparesis. We would like to make some observations that ...
|
Vivek V. Gumaste
|
685-686
|
|
|
|
Reply
05 March 2012
We appreciate the comments from Dr Gumaste regarding our article, “Similarities and differences between diabetic and idiopathic gastroparesis,” and the opportunity to discuss his comments. Our series ...
|
Henry P. Parkman,
William L. Hasler,
Linda Nguyen,
Pankaj J. Pasricha,
William J. Snape,
Gianrico Farrugia,
Kenneth L. Koch,
Jorge Calles,
Thomas L. Abell,
Richard W. McCallum,
Katherine Yates,
Linda Lee,
Aynur Unalp–Arida,
James Tonascia,
Frank Hamilton
et al.
|
686-687
|
|
|
|
Correction
18 April 2012
Sahebjalal M, Blackman J, McLaughlin S. The reintroduction of antiplatelet agents post gastrointestinal haemorrhage: a retrospective cross-sectional study and proposed management algorithm. Clin Gastr...
|
|
687
|
|
|
|
Cover
|
|
OFC
|
|
| Frontmatter |
| Images of the Month |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Adenocarcinoma Complicating Ulcerative Colitis Presenting as Multiple Pseudopolyp-like Lesions
09 December 2011
|
Matthew J. Hamilton,
Tanya A. Rege,
Robert D. Odze
|
A25
|
|
|
|
Ectopic Thyroid Presenting as a Liver Mass
10 January 2012
A 71-year-old woman presented for evaluation of dysfunctional uterine bleeding. Physical exam and labs were unremarkable. Transvaginal ultrasound revealed intrauterine fibroids but incidentally showed...
|
Maher Salam,
Abeer Mohideen,
Richard T. Stravitz
|
A30
|
|
|
|
Ectopic Sebacious Glands in the Esophageal Mucosa
16 February 2012
A 52-year-old white woman was referred to our department for further evaluation of pain in the right upper abdomen. Her past medical history was significant for gastroesophageal reflux disease and rhe...
|
Febin John,
Vasudevan Unnithan Raghuraman,
James R. Taylor
|
A32
|
|
|
|
Editorial Board
|
|
A4
|
|
|
|
Contents
|
|
A9-A12
|
|
|
|
Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute br...
|
|
A18-A19
|
|
|
|
Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship
In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for ot...
|
|
A24
|
|
