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November 2009 Vol. 7, No. 11

Editor's Essential Reading

Perspective

United States Health Care Reform in 2009: A Primer for Gastroenterologists

Spencer D. Dorn

The US health care system is characterized by staggering costs alongside limited access, uneven quality, and subpar health outcomes. Although federal policymakers have long acknowledged this health care crisis, there still has been no fundamental realignment in health care organization or delivery. With a new Presidential Administration and deep economic recession, profound changes now appear imminent.


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Clinical Gastroenterology and Hepatology is the go-to resource for readers interested in a broad spectrum of themes in clinical gastroenterology and hepatology. Its current impact factor is 5.465. More...

Issue Highlights

Editorial

Chronic Diarrhea Due to Excessive Bile Acid Synthesis and Not Defective Ileal Transport: A New Syndrome of Defective Fibroblast Growth Factor 19 Release

Alan F. Hofmann, David J. Mangelsdorf, Steven A. Kliewer

Original Articles—Alimentary Tract

Optimized Protocol for Diagnosis of Acute Ileitis

Elena Garrido, Antonio L. Sanromán, Miguel A. Rodríguez–Gandía, Miguel Rivero, Ana Royuela, Víctor Moreira, José María Milicua

A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis

Julian R.F. Walters, Ali M. Tasleem, Omer S. Omer, W. Gordon Brydon, Tracy Dew, Carel W. le Roux

Timing of Myelosuppression During Thiopurine Therapy for Inflammatory Bowel Disease: Implications for Monitoring Recommendations

James D. Lewis, Oren Abramson, Monina Pascua, Liyan Liu, Laura M. Asakura, Fernando S. Velayos, Susan M. Hutfless, James E. Alison, Lisa J. Herrinton

Fewer Polyps Detected by Colonoscopy as the Day Progresses at a Veteran's Administration Teaching Hospital

Michael Y. Chan, Hartley Cohen, Brennan M.R. Spiegel

Original Articles—Liver, Pancreas, and Biliary Tract

Independent Predictors of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Noreen Hossain, Arian Afendy, Maria Stepanova, Fatema Nader, Manirath Srishord, Nila Rafiq, Zachary Goodman, Zobair Younossi

Pancreas and Liver Injury Are Associated in Individuals With Increased Alcohol Consumption

Andrea Pace, Andreas de Weerth, Marc Berna, Katharina Hillbricht, Michael Tsokos, Michael Bläker, Klaus Pueschel, Ansgar W. Lohse

Early Systemic Inflammatory Response Syndrome Is Associated With Severe Acute Pancreatitis

Vikesh K. Singh, Bechien U. Wu, Thomas L. Bollen, Kathryn Repas, Rie Maurer, Koenraad J. Mortele, Peter A. Banks
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Top 10 Most Read Articles

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Sleep-Related Gastroesophageal Reflux: Evidence Is Mounting …

Susan M. Harding

Ruptured Hepatoma With Hemorrhagic Ascites

Darren Keller, Thomas Capozza, Erin Gable

Melanosis Coli

Dan Li, L. Walden Browne, Uri Ladabaum


Top 20 Most Cited Articles

News and Announcements

New! CGH Supplemental Issue on Pancreatic and Biliary Disease

Read the November 2009 supplement to CGH, “Inflammation and Carcinogenesis in the Pancreas and Biliary Tract: Mechanism and Practice”. Based on the proceedings from the fifth annual joint meeting of the AGA and the Japanese Society of Gastroenterology, world-renowned experts present information about the mechanisms, emerging diagnostic modalities, and natural history of pancreatobiliary disease.

Clinical Gastroenterology and Hepatology in the News

CGH has been featured in The Washington Post and Reuters!

Read recent press releases.

Take a Thirty-Second Survey!

Research about the science and practice of gastroenterology and hepatology is evolving faster than ever before. Tell Editor Mel Wilcox how to provide you with new information in ways that suit your busy lifestyle by taking this thirty-second, one-question survey.

AGA Institute Course on Sedation

To learn more about the administration of sedation, attend the AGA Institute’s course, Sedation Competencies for the Endoscopy Team: A Hands-on Course for Gastroenterologists and Nurses on Jan. 17, 2010 in Las Vegas. View details at www.gilearn.org/sedationcourse.

2008 Journal Rankings

Gastroenterology is again first in a field of 55 digestive disease journals according to its 2008 impact factor of 12.6. In its second year on the list, CGH placed eighth, with an impact factor of 6.1, up from 5.5. Congratulations to all journal editors!

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Readers of Gastroenterology and Clinical Gastroenterology and Hepatology (CGH) can now keep abreast of the journals' most recent and compelling research via the convenience of Facebook. Click here to learn more.


More news and announcements

Image of the Month

Peutz–Jeghers Syndrome: A Rare Cause of Gastric Outlet Obstruction

Shannon Chang, John Kalarickal, Virendra Joshi

A 16-year-old female patient with notable mucocutaneous pigmentation and a history of recurrent small bowel intussusception presented with a gastric outlet obstruction. A computed tomography scan revealed a large mass in the region of the gastric antrum obstructing the pylorus.


Review

Evidence for Endoscopic Ulcers as Meaningful Surrogate Endpoint for Clinically Significant Upper Gastrointestinal Harm

Andrew Moore, Ingvar Bjarnason, Byron Cryer, Luis Garcia–Rodriguez, Larry Goldkind, Angel Lanas, Lee Simon

Surrogate endpoints are biomarkers intended to substitute for a clinical endpoint. Are endoscopic ulcers a useful surrogate endpoint for a biological progression to clinical endpoints of ulcer complications (perforation, ulcers, and bleeds), hospital admission, or death?


Education Practice

A 38-Year-Old With Recurrent Colitis. Is It Noncompliance?

Sunanda Kane

A 38-year-old man with a 5 year history of ulcerative colitis presents for follow-up. He was diagnosed at age 33 when he presented with diarrhea, bleeding, urgency cramps, and weight loss. He was treated with a short course of prednisone and has never been hospitalized for his disease.