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Cover 1
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OFC
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| Introduction |
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Viral Hepatitis at a Crossroad
Every May, Gastroenterology publishes a supplementary issue, the “13th Issue”, that is devoted to a specific topic or theme. When the 2012 theme was discussed by the new Board of Editors (each member...
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Anna S.F. Lok,
Jean-Michel Pawlotsky
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1261-1263
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| Epidemiology and Pathophysiology |
| Review |
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Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma
Most cases of hepatocellular carcinoma (HCC) are associated with cirrhosis related to chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. Changes in the time trends of HCC and most v...
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Hashem B. El-Serag
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1264-1273.e1
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| Commentary |
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Is Hepatitis C Virus Carcinogenic?
No one would argue with the notion that chronic infection with hepatitis C virus (HCV) causes hepatocellular carcinoma (HCC). Early observations of the association between post-transfusion non-A, non-...
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Stanley M. Lemon,
David R. McGivern
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1274-1278
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| Review |
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Animal Models for the Study of Hepatitis C Virus Infection and Related Liver Disease
Hepatitis C virus (HCV) causes liver-related death in more than 300,000 people annually. Treatments for patients with chronic HCV are suboptimal, despite the introduction of directly acting antiviral ...
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Jens Bukh
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1279-1287.e3
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| Commentary |
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HCV Infection and Metabolic Syndrome: Which Is the Chicken and Which Is the Egg?
Hepatitis C virus (HCV) causes chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma. The World Health Organization estimates that approximately 2.35% of the world populatio...
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Francesco Negro
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1288-1292
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| Diagnostic and Prognostic Markers and Tools |
| Review |
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Noninvasive Methods to Assess Liver Disease in Patients With Hepatitis B or C
The prognosis and management of patients with chronic viral hepatitis B and C depend on the amount and progression of liver fibrosis and the risk for cirrhosis. Liver biopsy, traditionally considered ...
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Laurent Castera
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1293-1302.e4
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New Virologic Tools for Management of Chronic Hepatitis B and C
Molecular biology techniques are routinely used to diagnose and monitor treatment of patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. These tools can detect and qu...
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Stéphane Chevaliez,
Christophe Rodriguez,
Jean–Michel Pawlotsky
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1303-1313.e1
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| Therapeutic and Preventive Developments |
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Maximizing Opportunities and Avoiding Mistakes in Triple Therapy for Hepatitis C Virus
Recently developed drugs and innovative strategies for the treatment of chronic infection with genotype 1 hepatitis C virus (HCV) have become the standard of care. The protease inhibitors telaprevir (...
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A. Sidney Barritt,
Michael W. Fried
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1314-1323.e1
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Management of Patients Coinfected With HCV and HIV: A Close Look at the Role for Direct-Acting Antivirals
With the development of effective therapies against human immunodeficiency virus (HIV), hepatitis C virus (HCV) infection has become a major cause of morbidity and mortality among patients with both i...
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Susanna Naggie,
Mark S. Sulkowski
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1324-1334.e3
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| Commentary |
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Genetic Factors and Hepatitis C Virus Infection
It is now possible to comprehensively screen the human genome for genetic variation that influences the outcomes of human disease and pharmacotherapy. The most popular approach remains the genome-wid...
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Alexander J. Thompson
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1335-1339
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| Review |
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Anti−Hepatitis C Virus Drugs in Development
Development of robust cell culture models for hepatitis C viral infection has greatly increased our understanding of this virus and its life cycle. This knowledge has led to the development of many dr...
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Esperance A.K. Schaefer,
Raymond T. Chung
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1340-1350.e1
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| Commentary |
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Will Interferon-Free Regimens Prevail?
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Christoph Welsch,
Stefan Zeuzem
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1351-1355
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Is There a Role for Ribavirin in the Era of Hepatitis C Virus Direct-Acting Antivirals?
The Protease Inhibition for Viral Evaluation (PROVE) 2 and PROVE 3 trials tested the efficacy of various regimens of telaprevir-combination therapy in treatment-naïve and treatment-experienced patien...
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Jordan J. Feld
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1356-1359
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| Review |
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Effectiveness of Hepatitis B Treatment in Clinical Practice
It is important to examine the effectiveness of current therapies for chronic hepatitis B in clinical practice, given the therapeutic advances over the past 15 years. A 2010 Institute of Medicine repo...
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Steven J. Scaglione,
Anna S.F. Lok
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1360-1368.e1
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Is Hepatitis Virus Resistance to Antiviral Drugs a Threat?
The onset of the acquired immune deficiency syndrome epidemic in the early 1980s led to successful antiviral drug discovery programs, which brought to the market a large number of antiretroviral drug...
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Jean–Michel Pawlotsky
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1369-1372
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| Review |
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Viral Hepatitis in Liver Transplantation
Liver transplantation is the only alternative for patients with end-stage liver disease. Viral hepatitis B and C are among the most common causes of cirrhosis and hepatocellular carcinoma and a freque...
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Gonzalo Crespo,
Zoe Mariño,
Miquel Navasa,
Xavier Forns
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1373-1383.e1
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Will There Be a Vaccine to Protect Against the Hepatitis C Virus?
The discovery of the hepatitis C virus (HCV) more than 20 years ago offered the promise of a vaccine to prevent life-long persistent infection and associated progressive liver diseases. To date, only...
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Benoît Callendret,
Christopher M. Walker
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1384-1387
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| Hepatitis E Virus |
| Review |
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Pathogenesis and Treatment of Hepatitis E Virus Infection
Hepatitis E has been considered to be a travel-associated, acute, self-limiting liver disease that causes fulminant hepatic failure in specific high-risk groups only. However, hepatitis E virus (HEV) ...
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Heiner Wedemeyer,
Sven Pischke,
Michael P. Manns
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1388-1397.e1
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Editorial Board
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A2
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Table of Contents
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A7-A8
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Information for Authors and Readers
Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroentero...
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A10-A11
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Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship
Copyright Assignment. In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Ma...
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A16
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