| | Editor's Essential ReadingClinical—Alimentary TractKonstantinos Karmiris, Gilles Paintaud, Maja Noman, Charlotte Magdelaine–Beuzelin, Marc Ferrante, Danielle Degenne, Karolien Claes, Tamara Coopman, Nele Van Schuerbeek, Gert Van Assche, Severine Vermeire, Paul Rutgeerts
Adalimumab is an efficacious therapy for active Crohn’s disease, but long-term data are scarce. We conducted an observational study to assess the long-term clinical benefit of adalimumab in patients who failed to respond to infliximab, specifically focusing on the influence of trough serum concentration and antibodies against adalimumab on clinical outcome. A total of 168 patients with Crohn’s disease treated with adalimumab in a tertiary center were included in a prospective follow-up program.
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Gastroenterology, the official journal of the AGA Institute, is the number one journal in the field of gastrointestinal disease and ranks in the top one percent of all biomedical journals.
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| Issue HighlightsClinical—Alimentary Tract |  |
Chun–Ying Wu, Ken N. Kuo, Ming–Shiang Wu, Yi–Ju Chen, Chang–Bi Wang, Jaw–Town Lin
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Elena Stoffel, Bhramar Mukherjee, Victoria M. Raymond, Nabihah Tayob, Fay Kastrinos, Jennifer Sparr, Fei Wang, Prathap Bandipalliam, Sapna Syngal, Stephen B. Gruber
| Clinical Advances in Liver, Pancreas, and Biliary Tract |  |
Loes van Keimpema, Frederik Nevens, Ragna Vanslembrouck, Martijn G.H. van Oijen, Aswin L. Hoffmann, Helena M. Dekker, Robert A. de Man, Joost P.H. Drenth
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Pedro Zapater, Rocío Caño, Lucía Llanos, Antonio J. Ruiz–Alcaraz, Sonia Pascual, Claudia Barquero, Rocío Moreu, Pablo Bellot, José F. Horga, Carlos Muñoz, Jara Pérez, Pilar García–Peñarrubia, Miguel Pérez–Mateo, José Such, Rubén Francés
| Basic—Alimentary Tract |  |
Atsushi Sakuraba, Toshiro Sato, Nobuhiko Kamada, Mina Kitazume, Akira Sugita, Toshifumi Hibi
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Marie A. Hildebrandt, Christian Hoffmann, Scott A. Sherrill–Mix, Sue A. Keilbaugh, Micah Hamady, Ying–Yu Chen, Rob Knight, Rexford S. Ahima, Frederic Bushman, Gary D. Wu
| Basic—Liver, Pancreas, and Biliary Tract |  |
Menashe Elazar, Michael Liu, Sean A. McKenna, Ping Liu, Elizabeth A. Gehrig, Joseph D. Puglisi, Jean–François Rossignol, Jeffrey S. Glenn
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Charis L. Johnson, Jacqueline Y. Weston, Sami A. Chadi, Elena N. Fazio, Murray W. Huff, Alexei Kharitonenkov, Anja Köester, Christopher L. Pin
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Ganapathy A. Prasad, Tsung Teh Wu, Dennis A. Wigle, Navtej S. Buttar, Louis–Michel Wongkeesong, Kelly T. Dunagan, Lori S. Lutzke, Lynn S. Borkenhagen, Kenneth K. Wang
Manmeet S. Padda, Harry R. Aslanian, C. Theoharis
Christina Reimer, Bo Søndergaard, Linda Hilsted, Peter Bytzer
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Top 20 Most Cited Articles | |
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New! Gastroenterology Supplemental Issue on Micronutrient Dosing
Read the November 2009 supplement to Gastroenterology, "Micronutrients in Parenteral Nutrition: Too Little or Too Much?". Based on proceedings from this year's annual American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Research Workshop, leading international experts present the latest information on correct dosages of parenteral vitamins and trace elements. Gastroenterology in the News
Gastroenterology has been featured in The New York Times, The New York Times Well Blog, the Guardian, Reuters, and on NPR! Read recent press releases.
Take a Thirty-Second Survey!
Research about the science and practice of gastroenterology and hepatology is evolving faster than ever before. Tell Editor Anil Rustgi how to provide you with new information in ways that suit your busy lifestyle by taking this thirty-second, one-question survey. AGA Institute Course on Sedation
To learn more about the administration of sedation, attend the AGA Institute’s course, Sedation Competencies for the Endoscopy Team: A Hands-on Course for Gastroenterologists and Nurses on Jan. 17, 2010 in Las Vegas. View details at www.gilearn.org/sedationcourse.
2008 Journal Rankings
Gastroenterology is again first in a field of 55 digestive disease journals according to its 2008 impact factor of 12.6. In its second year on the list, CGH placed eighth, with an impact factor of 6.1, up from 5.5. Congratulations to all journal editors!
Join Gastroenterology and CGH on Facebook®
Readers of Gastroenterology and Clinical Gastroenterology and Hepatology (CGH) can now keep abreast of the journals' most recent and compelling research via the convenience of Facebook. Click here to learn more. Gastroenterology Special Issue
Read this year's special 13th issue entitled "Intestinal Microbes in Health and Disease." Experts explore the pivotal role of microbiota in the health of the intestine and pathogenic mechanisms underlying key gastrointestinal infections as well as important treatment considerations. More news and announcements |
Review
Hepatitis B Virus Resistance to Nucleos(t)ide Analogues
Fabien Zoulim, Stephen Locarnini
Patients with chronic hepatitis B (CHB) can be successfully treated using nucleos(t)ide analogs (NA), but drug-resistant hepatitis B virus (HBV) mutants frequently arise, leading to treatment failure and progression to liver disease. There has been much research into the mechanisms of resistance to NA and selection of these mutants.
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Imaging and Advanced Technology |
Editorial
Pathogen-Specific Antibody: Cause or Effect?
Tadakazu Hisamatsu, Toshifumi Hibi
The serologic markers for inflammatory bowel disease (IBD) commonly used for diagnostic tools are antineutrophil cytoplasmic antibodies for ulcerative colitis (UC) and anti-Saccharomyces cerevisiae antibodies, which target mannose residues on mannan in the cell wall of the yeast S cerevisiae, for Crohn’s disease (CD).
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