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Issue Highlights
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A17
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| Feature Article |
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Oncology Scan – Thoracic Cancers
National Lung Screening Trial Research Team, Aberle DR, Adams AM, Berg CD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011;365(5):395-409. Epub 201...
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Mitchell Machtay
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765-767
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| Comments |
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Cervical Neck Dissection for Complete Responders in Head-and-Neck: A Utilitarian Ideal? In regard to Thariat et al “Prediction of Neck Dissection Requirement After Definitive Radiotherapy for Head-and-Neck Squamous Cell Carcinoma.” (Int J Radiat Oncol Biol Phys 2012;82:e367–e374)
To the Editor: Thariat et al have validated their institutional preference by predicting low rates of locoregional recurrence in completely responding N2-N3 cervical neck nodes but it does not includ...
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Abhishek Puri
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768
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In regard to “Impact of [11C]Methionine Positron Emission Tomography for Target Definition of Glioblastoma Multiforme in Radiation Therapy Planning.” (Int J Radiat Oncol Biol Phys 2012;82:83–89)
To the Editor: The authors address an important question with which we wrestled for a long time: What is the most appropriate magnetic resonance imaging (MRI)–based clinical target volume (CTV) for t...
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Moshe H. Maor
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769
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Re-Irradiation Strategies for Head-and-Neck Cancers: Implications for Stereotactic Body Radiotherapy: In regard to Chen et al (Int J Radiant Oncol Biol Phys 2011;81:1211–1219)
To the Editor: We read with interest the review by Chen et al eloquently outlining considerations for re-irradiation in unresectable, locally recurrent, and second-primary head-and-neck cancers (rHNC)...
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John A. Vargo,
Dwight E. Heron,
Robert L. Ferris,
Jean-Claude M. Rwigema,
Rodney E. Wegner
et al.
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769-770
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| Editorial |
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National Residency Matching Program (NRMP) Results for Radiation Oncology: 2011 Update
Radiation oncology continues to be a very competitive specialty in which to obtain a residency training position in the United States. Although application numbers previously were thought to have leve...
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Sanjay Aneja,
Lynn D. Wilson,
Bruce G. Haffty,
James B. Yu
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771-772
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| Critical Reviews |
| Quality |
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Quality Assessment in Oncology
23 March 2012
The movement to improve healthcare quality has led to a need for carefully designed quality indicators that accurately reflect the quality of care. Many different measures have been proposed and conti...
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Jeffrey M. Albert,
Prajnan Das
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773-781
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Redesigning Radiotherapy Quality Assurance: Opportunities to Develop an Efficient, Evidence-Based System to Support Clinical Trials—Report of the National Cancer Institute Work Group on Radiotherapy Quality Assurance
16 March 2012
Purpose: In the context of national calls for reorganizing cancer clinical trials, the National Cancer Institute sponsored a 2-day workshop to examine challenges and opportunities for optimizing radio...
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Justin E. Bekelman,
James A. Deye,
Bhadrasain Vikram,
Soren M. Bentzen,
Deborah Bruner,
Walter J. Curran,
James Dignam,
Jason A. Efstathiou,
T.J. FitzGerald,
Coen Hurkmans,
Geoffrey S. Ibbott,
J. Jack Lee,
Thomas E. Merchant,
Jeff Michalski,
Jatinder R. Palta,
Richard Simon,
Randal K. Ten Haken,
Robert Timmerman,
Sean Tunis,
C. Norman Coleman,
James Purdy
et al.
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782-790
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| Clinical Investigations |
| Breast Cancers |
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Accelerated Partial Breast Irradiation With Low-Dose-Rate Interstitial Implant Brachytherapy After Wide Local Excision: 12-Year Outcomes From a Prospective Trial
17 November 2011
Purpose: To evaluate the long-term toxicity, cosmesis, and local control of accelerated partial breast irradiation with implant brachytherapy after wide local excision for Stage T1N0 breast cancer (BC...
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Jona A. Hattangadi,
Simon N. Powell,
Shannon M. MacDonald,
Thomas Mauceri,
Marek Ancukiewicz,
Phoebe Freer,
Brian Lawenda,
Mohamed A. Alm El-Din,
Michele A. Gadd,
Barbara L. Smith,
Alphonse G. Taghian
et al.
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791-800
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Factors Associated With Chest Wall Toxicity After Accelerated Partial Breast Irradiation Using High-Dose-Rate Brachytherapy
16 January 2012
Purpose: The purpose of this analysis was to evaluate dose-volume relationships associated with a higher probability for developing chest wall toxicity (pain) after accelerated partial breast irradiat...
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Sheree Brown,
Frank Vicini,
Jyotsna R. Vanapalli,
Thomas J. Whitaker,
D. Keith Pope,
Maureen Lyden,
Lisa Bruggeman,
Kenneth L. Haile,
Mark P. McLaughlin
et al.
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801-805
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How Do the ASTRO Consensus Statement Guidelines for the Application of Accelerated Partial Breast Irradiation Fit Intraoperative Radiotherapy? A Retrospective Analysis of Patients Treated at the European Institute of Oncology
16 January 2012
Purpose: To verify how the classification according to the American Society for Therapeutic Radiation Oncology (ASTRO) consensus statement (CS) for the application of accelerated partial breast irradi...
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Maria Cristina Leonardi,
Patrick Maisonneuve,
Mauro Giuseppe Mastropasqua,
Anna Morra,
Roberta Lazzari,
Nicole Rotmensz,
Claudia Sangalli,
Alberto Luini,
Umberto Veronesi,
Roberto Orecchia
et al.
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806-813
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Breast Conservation Therapy: The Influence of Molecular Subtype and Margins
29 December 2011
Purpose: To evaluate treatment results and prognostic factors, especially margin status and molecular subtype, in early-stage breast cancer patients treated with breast conservation therapy (BCT). Met...
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Senem Demirci,
Gloria Broadwater,
Lawrence B. Marks,
Robert Clough,
Leonard R. Prosnitz
et al.
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814-820
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Prone Whole-Breast Irradiation Using Three-Dimensional Conformal Radiotherapy in Women Undergoing Breast Conservation for Early Disease Yields High Rates of Excellent to Good Cosmetic Outcomes in Patients With Large and/or Pendulous Breasts
29 December 2011
Purpose: To report our institution's experience using prone positioning for three-dimensional conformal radiotherapy (3D-CRT) to deliver post-lumpectomy whole breast irradiation (WBI) in a cohort of w...
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Carmen Bergom,
Tracy Kelly,
Natalya Morrow,
J. Frank Wilson,
Alonzo Walker,
Qun Xiang,
Kwang Woo Ahn,
Julia White
et al.
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821-828
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Impact of Screening and Risk Factors for Local Recurrence and Survival After Conservative Surgery and Radiotherapy for Early Breast Cancer: Results From a Large Series With Long-Term Follow-Up
23 December 2011
Purpose: To investigate conventional prognostic factors for ipsilateral breast tumor recurrence (IBTR), distant metastasis (DM), and survival after breast-conserving therapy (BCT) in screen-detected a...
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Ian H. Kunkler,
Gillian R. Kerr,
Jeremy S. Thomas,
Wilma J.L. Jack,
John M.S. Bartlett,
Hans C. Pedersen,
David A. Cameron,
J. Michael Dixon,
Udi Chetty,
Edinburgh Breast Group
et al.
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829-838
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Cosmetic Outcomes and Complications Reported by Patients Having Undergone Breast-Conserving Treatment
05 December 2011
Purpose: Over the past 30 years, much work in treatment of breast cancer has contributed to improvement of cosmetic and functional outcomes. The goal of breast-conservation treatment (BCT) is avoidanc...
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Christine E. Hill-Kayser,
Carolyn Vachani,
Margaret K. Hampshire,
Gloria A. Di Lullo,
James M. Metz
et al.
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839-844
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Influence of Lymphatic Invasion on Locoregional Recurrence Following Mastectomy: Indication for Postmastectomy Radiotherapy for Breast Cancer Patients With One to Three Positive Nodes
05 December 2011
Purpose: The indication for postmastectomy radiotherapy (PMRT) in breast cancer patients with one to three positive lymph nodes has been in discussion. The purpose of this study was to identify patien...
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Ryoichi Matsunuma,
Masahiko Oguchi,
Tomoko Fujikane,
Masaaki Matsuura,
Takehiko Sakai,
Kiyomi Kimura,
Hidetomo Morizono,
Kotaro Iijima,
Ayumi Izumori,
Yumi Miyagi,
Seiichiro Nishimura,
Masujiro Makita,
Naoya Gomi,
Rie Horii,
Futoshi Akiyama,
Takuji Iwase
et al.
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845-852
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Preradiotherapy Calcium Scores of the Coronary Arteries in a Cohort of Women With Early-Stage Breast Cancer: A Comparison With a Cohort of Healthy Women
05 December 2011
Purpose: Breast cancer radiotherapy has been associated with an increased risk of cardiac toxicity. However, no data are available on the probability of developing coronary artery disease (CAD) in bre...
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Mirjam E. Mast,
Mark W. Heijenbrok,
Anna L. Petoukhova,
Astrid N. Scholten,
Joop H.M. Schreur,
Henk Struikmans
et al.
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853-858
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Long-Term Outcome in Patients With Ductal Carcinoma In Situ Treated With Breast-Conserving Therapy: Implications for Optimal Follow-up Strategies
14 March 2012
Purpose: To determine 20-year rates of local control and outcome-associated factors for ductal carcinoma in situ (DCIS) after breast-conserving therapy (BCT). Methods and Materials: All DCIS cases rec...
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Simona F. Shaitelman,
J. Ben Wilkinson,
Larry L. Kestin,
Hong Ye,
Neal S. Goldstein,
Alvaro A. Martinez,
Frank A. Vicini
et al.
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e305-e312
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Identifying Patients Who Are Unsuitable for Accelerated Partial Breast Irradiation Using Three-dimensional External Beam Conformal Techniques
14 March 2012
Purpose: Several recent studies reported that severe late toxicities including soft-tissue fibrosis and fat necrosis are present in patients treated with accelerated partial breast irradiation (APBI) ...
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Naoto Shikama,
Naoki Nakamura,
Naoaki Kunishima,
Shogo Hatanaka,
Kenji Sekiguchi
et al.
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e313-e318
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| Central Nervous System Tumors |
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Long-Term Outcome After Radiotherapy in Patients With Atypical and Malignant Meningiomas—Clinical Results in 85 Patients Treated in a Single Institution Leading to Optimized Guidelines for Early Radiation Therapy
05 December 2011
Purpose: Previously, we could show that the new World Health Organization (WHO) classification of meningiomas significantly correlated with outcome in patients with atypical and anaplastic histology. ...
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Sebastian Adeberg,
Christian Hartmann,
Thomas Welzel,
Stefan Rieken,
Daniel Habermehl,
Andreas von Deimling,
Jürgen Debus,
Stephanie E. Combs
et al.
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859-864
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Spot Scanning-Based Proton Therapy for Intracranial Meningioma: Long-Term Results From the Paul Scherrer Institute
05 December 2011
Background: To assess the long-term clinical results of spot scanning proton therapy (PT) in the treatment of intracranial meningiomas. Patients and Methods: Thirty-nine patients with meningioma (hist...
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Damien C. Weber,
Ralf Schneider,
Gudrun Goitein,
Tamara Koch,
Carmen Ares,
Jan H. Geismar,
Andreas Schertler,
Alessandra Bolsi,
Eugen B. Hug
et al.
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865-871
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Factors Predictive of Symptomatic Radiation Injury After Linear Accelerator-Based Stereotactic Radiosurgery for Intracerebral Arteriovenous Malformations
29 December 2011
Purpose: To investigate predictive factors in the development of symptomatic radiation injury after treatment with linear accelerator–based stereotactic radiosurgery for intracerebral arteriovenous ma...
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Christopher Herbert,
Vitali Moiseenko,
Michael McKenzie,
Gary Redekop,
Fred Hsu,
Ermias Gete,
Brad Gill,
Richard Lee,
Kurt Luchka,
Charles Haw,
Andrew Lee,
Brian Toyota,
Montgomery Martin
et al.
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872-877
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Phase Measurement of Cognitive Impairment Specific to Radiotherapy
14 March 2012
Purpose: Memory impairment is an early-delayed effect of radiotherapy (RT). The prospective longitudinal measurement of the cognitive phase effects from RT was conducted on treated and untreated brain...
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Carol L. Armstrong,
David M. Shera,
Robert A. Lustig,
Peter C. Phillips
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e319-e324
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Prognostic Indexes for Brain Metastases: Which Is the Most Powerful?
Purpose: The purpose of the present study was to compare the prognostic indexes (PIs) of patients with brain metastases (BMs) treated with whole brain radiotherapy (WBRT) using an artificial neural ne...
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Gustavo Arruda Viani,
Lucas Godói Bernardes da Silva,
Eduardo Jose Stefano
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e325-e330
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| Metastases |
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Oligometastases Treated With Stereotactic Body Radiotherapy: Long-Term Follow-Up of Prospective Study
14 December 2011
Purpose: To analyze the long-term survival and tumor control outcomes after stereotactic body radiotherapy (SBRT) for metastases limited in number and extent. Methods and Materials: We prospectively a...
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Michael T. Milano,
Alan W. Katz,
Hong Zhang,
Paul Okunieff
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878-886
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| Gastrointestinal Cancers |
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Radioembolization for Neuroendocrine Liver Metastases: Safety, Imaging, and Long-Term Outcomes
05 December 2011
Purpose: To present long-term outcomes on the safety and efficacy of Yttrium-90 radioembolization in the treatment of unresectable hepatic neuroendocrine metastases refractory to standard-of-care ther...
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Khairuddin Memon,
Robert J. Lewandowski,
Mary F. Mulcahy,
Ahsun Riaz,
Robert K. Ryu,
Kent T. Sato,
Ramona Gupta,
Paul Nikolaidis,
Frank H. Miller,
Vahid Yaghmai,
Vanessa L. Gates,
Bassel Atassi,
Steven Newman,
Reed A. Omary,
Al B. Benson,
Riad Salem
et al.
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887-894
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Stereotactic Hypofractionated Radiation Therapy as a Bridge to Transplantation for Hepatocellular Carcinoma: Clinical Outcome and Pathologic Correlation
14 December 2011
Purpose: We sought to determine efficacy, safety, and outcome of stereotactic hypofractionated radiation therapy (SHORT) as a suitable bridging therapy for patients awaiting liver transplantation (LT)...
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Alan W. Katz,
Sheema Chawla,
Zhenhong Qu,
Randeep Kashyap,
Michael T. Milano,
Aram F. Hezel
et al.
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895-900
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Radiation Therapy Oncology Group Consensus Panel Guidelines for the Delineation of the Clinical Target Volume in the Postoperative Treatment of Pancreatic Head Cancer
06 April 2012
Purpose: To develop contouring guidelines to be used in the Radiation Therapy Oncology Group protocol 0848, a Phase III randomized trial evaluating the benefit of adjuvant chemoradiation in patients w...
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Karyn A. Goodman,
William F. Regine,
Laura A. Dawson,
Edgar Ben-Josef,
Karin Haustermans,
Walter R. Bosch,
Julius Turian,
Ross A. Abrams
et al.
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901-908
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Prognostic Factors for Survival and Resection in Patients With Initial Nonresectable Locally Advanced Pancreatic Cancer Treated With Chemoradiotherapy
14 December 2011
Background and Purpose: Controversies regarding the optimal therapy for patients with locally advanced pancreatic cancer (LAPC) exist. Although the prognosis as a whole remains dismal, subgroups are k...
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Jon K. Bjerregaard,
Michael B. Mortensen,
Helle A. Jensen,
Morten Nielsen,
Per Pfeiffer
et al.
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909-915
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Analysis of Local Control in Patients Receiving IMRT for Resected Pancreatic Cancers
27 January 2012
Purpose: Intensity-modulated radiotherapy (IMRT) is increasingly incorporated into therapy for pancreatic cancer. A concern regarding this technique is the potential for geographic miss and decreased ...
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Susannah Yovino,
Bert W. Maidment,
Joseph M. Herman,
Naimish Pandya,
Olga Goloubeva,
Chris Wolfgang,
Richard Schulick,
Daniel Laheru,
Nader Hanna,
Richard Alexander,
William F. Regine
et al.
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916-920
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Radiation Therapy With Full-Dose Gemcitabine and Oxaliplatin for Unresectable Pancreatic Cancer
29 December 2011
Purpose: We completed a Phase I trial of gemcitabine and oxaliplatin with concurrent radiotherapy in patients with previously untreated pancreatic cancer. The results of a subset of patients with unre...
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Klaudia U. Hunter,
Felix Y. Feng,
Kent A. Griffith,
Isaac R. Francis,
Theodore S. Lawrence,
Sameer Desai,
James D. Murphy,
Mark M. Zalupski,
Edgar Ben-Josef
et al.
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921-926
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Survival After Chemoradiation in Resected Pancreatic Cancer: The Impact of Adjuvant Gemcitabine
14 March 2012
Purpose: To evaluate survival in patients with resected pancreatic cancer treated with concurrent chemoradiation with or without adjuvant gemcitabine (Gem). Methods and Materials: From 1998 to 2010, 8...
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Andrew Baschnagel,
Chirag Shah,
Jeffrey Margolis,
Laura Nadeau,
Julie Stein,
Robert Jury,
John M. Robertson
et al.
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e331-e335
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Pancreatic Neuroendocrine Tumors With Involved Surgical Margins: Prognostic Factors and the Role of Adjuvant Radiotherapy
12 March 2012
Purpose: Pancreatic neuroendocrine tumors (pNET) are rare neoplasms associated with poor outcomes without resection, and involved surgical margins are associated with a worse prognosis. The role of ad...
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Nils D. Arvold,
Christopher G. Willett,
Carlos Fernandez-del Castillo,
David P. Ryan,
Cristina R. Ferrone,
Jeffrey W. Clark,
Lawrence S. Blaszkowsky,
Vikram Deshpande,
Andrzej Niemierko,
Jill N. Allen,
Eunice L. Kwak,
Raymond C. Wadlow,
Andrew X. Zhu,
Andrew L. Warshaw,
Theodore S. Hong
et al.
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e337-e343
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Proton Beam Therapy and Concurrent Chemotherapy for Esophageal Cancer
14 March 2012
Purpose: Proton beam therapy (PBT) is a promising modality for the management of thoracic malignancies. We report our preliminary experience of treating esophageal cancer patients with concurrent chem...
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Steven H. Lin,
Ritsuko Komaki,
Zhongxing Liao,
Caimiao Wei,
Bevan Myles,
Xiaomao Guo,
Matthew Palmer,
Radhe Mohan,
Stephen G. Swisher,
Wayne L. Hofstetter,
Jaffer A. Ajani,
James D. Cox
et al.
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e345-e351
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| Genitourinary Cancers |
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High-Dose-Rate Brachytherapy as Monotherapy Delivered in Two Fractions Within One Day for Favorable/Intermediate-Risk Prostate Cancer: Preliminary Toxicity Data
26 December 2011
Purpose: To report the toxicity profile of high-dose-rate (HDR)-brachytherapy (BT) as monotherapy in a Human Investigation Committee-approved study consisting of a single implant and two fractions (12...
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Michel Ghilezan,
Alvaro Martinez,
Gary Gustason,
Daniel Krauss,
J. Vito Antonucci,
Peter Chen,
James Fontanesi,
Michelle Wallace,
Hong Ye,
Alyse Casey,
Evelyn Sebastian,
Leonard Kim,
Amy Limbacher
et al.
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927-932
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Implementation of High-Dose-Rate Brachytherapy and Androgen Deprivation in Patients With Prostate Cancer
05 December 2011
Purpose: To evaluate outcome (overall survival [OS], the actuarial 5-year cancer-specific survival [CSS], disease-free survival [DFS], biochemical failure-free survival [BFS]), complications and morbi...
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Wolfgang Lilleby,
Gunnar Tafjord,
Nils K. Raabe
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933-939
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Percentage of Cancer Volume in Biopsy Cores Is Prognostic for Prostate Cancer Death and Overall Survival in Patients Treated With Dose-Escalated External Beam Radiotherapy
07 November 2011
Purpose: To investigate the prognostic utility of the percentage of cancer volume (PCV) in needle biopsy specimens for prostate cancer patients treated with dose-escalated external beam radiotherapy. ...
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Sean M. Vance,
Matthew H. Stenmark,
Kevin Blas,
Schulyer Halverson,
Daniel A. Hamstra,
Felix Y. Feng
et al.
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940-946
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Adaptive Image-Guided Radiotherapy (IGRT) Eliminates the Risk of Biochemical Failure Caused by the Bias of Rectal Distension in Prostate Cancer Treatment Planning: Clinical Evidence
29 December 2011
Purpose: Rectal distension has been shown to decrease the probability of biochemical control. Adaptive image-guided radiotherapy (IGRT) corrects for target position and volume variations, reducing the...
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Sean S. Park,
Di Yan,
Samuel McGrath,
Joshua T. Dilworth,
Jian Liang,
Hong Ye,
Daniel J. Krauss,
Alvaro A. Martinez,
Larry L. Kestin
et al.
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947-952
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Incidence of Secondary Cancer Development After High-Dose Intensity-Modulated Radiotherapy and Image-Guided Brachytherapy for the Treatment of Localized Prostate Cancer
14 December 2011
Purpose: To report the incidence and excess risk of second malignancy (SM) development compared with the general population after external beam radiotherapy (EBRT) and brachytherapy to treat prostate ...
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Michael J. Zelefsky,
Douglas M. Housman,
Xin Pei,
Zumre Alicikus,
Juan Martin Magsanoc,
Lawrence T. Dauer,
Jean St. Germain,
Yoshiya Yamada,
Marisa Kollmeier,
Brett Cox,
Zhigang Zhang
et al.
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953-959
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High-Dose Adjuvant Radiotherapy After Radical Prostatectomy With or Without Androgen Deprivation Therapy
14 December 2011
Purpose: To retrospectively evaluate the outcome and toxicity in patients receiving high-dose (>69 Gy) adjuvant radiotherapy (HD-ART) and the impact of androgen deprivation therapy (ADT). Methods a...
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Piet Ost,
Cesare Cozzarini,
Gert De Meerleer,
Claudio Fiorino,
Bruno De Potter,
Alberto Briganti,
Evi V.T. Nagler,
Francesco Montorsi,
Valérie Fonteyne,
Nadia Di Muzio
et al.
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960-965
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Pelvic Normal Tissue Contouring Guidelines for Radiation Therapy: A Radiation Therapy Oncology Group Consensus Panel Atlas
09 April 2012
Purpose: To define a male and female pelvic normal tissue contouring atlas for Radiation Therapy Oncology Group (RTOG) trials. Methods and Materials: One male pelvis computed tomography (CT) data set ...
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Hiram A. Gay,
H. Joseph Barthold,
Elizabeth O’Meara,
Walter R. Bosch,
Issam El Naqa,
Rawan Al-Lozi,
Seth A. Rosenthal,
Colleen Lawton,
W. Robert Lee,
Howard Sandler,
Anthony Zietman,
Robert Myerson,
Laura A. Dawson,
Christopher Willett,
Lisa A. Kachnic,
Anuja Jhingran,
Lorraine Portelance,
Janice Ryu,
William Small,
David Gaffney,
Akila N. Viswanathan,
Jeff M. Michalski
et al.
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e353-e362
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Clinical Outcome of Patients Treated With 3D Conformal Radiation Therapy (3D-CRT) for Prostate Cancer on RTOG 9406
Purpose: Report of clinical cancer control outcomes on Radiation Therapy Oncology Group (RTOG) 9406, a three-dimensional conformal radiation therapy (3D-CRT) dose escalation trial for localized adenoc...
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Jeff Michalski,
Kathryn Winter,
Mack Roach,
Arnold Markoe,
Howard M. Sandler,
Janice Ryu,
Matthew Parliament,
James A. Purdy,
Richard K. Valicenti,
James D. Cox
et al.
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e363-e370
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Implanted Dosimeters Identify Radiation Overdoses During IMRT for Prostate Cancer
Purpose: Image-guided dose-escalated radiotherapy is the standard of care for the treatment of prostate cancer. Although many published methods are available that account for prostate motion during de...
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Robert B. Den,
Kamila Nowak,
Ivan Buzurovic,
Junsheng Cao,
Amy S. Harrison,
Yaacov R. Lawrence,
Adam P. Dicker,
Timothy N. Showalter
et al.
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e371-e376
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| Gynecologic Cancers |
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Low-Dose-Rate Californium-252 Neutron Intracavitary Afterloading Radiotherapy Combined With Conformal Radiotherapy for Treatment of Cervical Cancer
05 December 2011
Purpose: To study the efficacy of low-dose-rate californium-252 (252Cf) neutron intracavitary afterloading radiotherapy (RT) combined with external pelvic RT for treatment of cervical cancer. Methods ...
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Min Zhang,
Hong-De Xu,
Song-Dan Pan,
Shan Lin,
Jian-Hua Yue,
Jian-Ren Liu
et al.
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966-971
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Characterizing Tumor Heterogeneity With Functional Imaging and Quantifying High-Risk Tumor Volume for Early Prediction of Treatment Outcome: Cervical Cancer as a Model
29 December 2011
Purpose: Treatment response in cancer has been monitored by measuring anatomic tumor volume (ATV) at various times without considering the inherent functional tumor heterogeneity known to critically i...
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Nina A. Mayr,
Zhibin Huang,
Jian Z. Wang,
Simon S. Lo,
Joline M. Fan,
John C. Grecula,
Steffen Sammet,
Christina L. Sammet,
Guang Jia,
Jun Zhang,
Michael V. Knopp,
William T.C. Yuh
et al.
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972-979
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Image-Based 3D Treatment Planning for Vaginal Cylinder Brachytherapy: Dosimetric Effects of Bladder Filling on Organs at Risk
05 December 2011
Purpose: To investigate the dosimetric effects of bladder filling on organs at risk (OARs) using three-dimensional image-based treatment planning for vaginal cylinder brachytherapy. Methods and Materi...
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Jennifer Hung,
Sui Shen,
Jennifer F. De Los Santos,
Robert Y. Kim
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980-985
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| Head and Neck Cancers |
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Article Title |
Author(s) |
Pages |
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Adaptive Radiotherapy for Head-and-Neck Cancer: Initial Clinical Outcomes From a Prospective Trial
05 December 2011
Purpose: To present pilot toxicity and survival outcomes for a prospective trial investigating adaptive radiotherapy (ART) for oropharyngeal squamous cell carcinoma. Methods and Materials: A total of ...
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David L. Schwartz,
Adam S. Garden,
Jimmy Thomas,
Yipei Chen,
Yongbin Zhang,
Jan Lewin,
Mark S. Chambers,
Lei Dong
et al.
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986-993
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A Planned Neck Dissection Is Not Necessary in All Patients With N2-3 Head-and-Neck Cancer After Sequential Chemoradiotherapy
05 December 2011
Purpose: To assess the role of a planned neck dissection (PND) after sequential chemoradiotherapy for patients with head-and-neck cancer with N2–N3 nodal disease. Methods and Materials: We reviewed 90...
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Scott G. Soltys,
Clara Y.H. Choi,
Willard E. Fee,
Harlan A. Pinto,
Quynh-Thu Le
et al.
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994-999
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A Single-Institutional Experience of 15 Years of Treating T3 Laryngeal Cancer With Primary Radiotherapy, With or Without Chemotherapy
17 November 2011
Purpose: To retrospectively analyze the outcomes, toxicity, quality of life, and voice quality of patients with T3 laryngeal cancer treated with radiotherapy and to identify subgroups of patients in w...
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Abrahim Al-Mamgani,
Lisa Tans,
Peter van Rooij,
Peter C. Levendag
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1000-1006
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Reducing Xerostomia After Chemo-IMRT for Head-and-Neck Cancer: Beyond Sparing the Parotid Glands
07 November 2011
Purpose: To assess whether, in addition to sparing the parotid glands (PGs), xerostomia after chemotherapy plus intensity-modulated radiotherapy (chemo-IMRT) for head-and-neck cancer is affected by re...
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Michael Little,
Matthew Schipper,
Felix Y. Feng,
Karen Vineberg,
Craig Cornwall,
Carol-Anne Murdoch-Kinch,
Avraham Eisbruch
et al.
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1007-1014
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Reirradiation With Cetuximab in Locoregional Recurrent and Inoperable Squamous Cell Carcinoma of the Head and Neck: Feasibility and First Efficacy Results
12 March 2012
Purpose: To report our experience with a prospective protocol of external beam reirradiation (Re-RT) combined with cetuximab for patients with inoperable, recurrent squamous cell carcinoma of the head...
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Panagiotis Balermpas,
Christian Keller,
Markus Hambek,
Jens Wagenblast,
Oliver Seitz,
Claus Rödel,
Christian Weiss
et al.
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e377-e383
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| Lymphoma |
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Article Title |
Author(s) |
Pages |
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Low-Dose Radiation Treatment in Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma: A Plausible Approach? A Single-Institution Experience in 10 Patients
14 March 2012
Purpose: To propose an alternative approach for treatment of pulmonary marginal zone lymphoma, using a very small radiation dose (2 × 2 Gy) delivered exclusively to tumor sites. Methods and Materials:...
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Theodore Girinsky,
Amaury Paumier,
Christophe Ferme,
Colette Hanna,
Vincent Ribrag,
François Leroy-Ladurie,
Mithra Ghalibafian
et al.
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e385-e389
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| Pediatric Cancer |
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Article Title |
Author(s) |
Pages |
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Proton Radiotherapy for High-Risk Pediatric Neuroblastoma: Early Outcomes and Dose Comparison
05 December 2011
Purpose: To report the early outcomes for children with high-risk neuroblastoma treated with proton radiotherapy (RT) and to compare the dose distributions for intensity-modulated photon RT (IMRT), th...
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Jona A. Hattangadi,
Barbara Rombi,
Torunn I. Yock,
George Broussard,
Alison M. Friedmann,
Mary Huang,
Yen-Lin E. Chen,
Hsiao-Ming Lu,
Hanne Kooy,
Shannon M. MacDonald
et al.
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1015-1022
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| Biology Contributions |
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Article Title |
Author(s) |
Pages |
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Intranuclear Delivery of a Novel Antibody-Derived Radiosensitizer Targeting the DNA-Dependent Protein Kinase Catalytic Subunit
05 December 2011
Purpose: To inhibit DNA double-strand break repair in tumor cells by delivery of a single-chain antibody variable region fragment (ScFv 18-2) to the cell nucleus. ScFv 18-2 binds to a regulatory regio...
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Hairong Xiong,
Robert J. Lee,
Eric B. Haura,
John G. Edwards,
William S. Dynan,
Shuyi Li
et al.
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1023-1030
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Spinal Cord Tolerance to Reirradiation With Single-Fraction Radiosurgery: A Swine Model
23 December 2011
Purpose: This study was performed to determine swine spinal cord tolerance to single-fraction, partial-volume irradiation 1 year after receiving uniform irradiation to 30 Gy in 10 fractions. Methods a...
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Paul M. Medin,
Ryan D. Foster,
Albert J. van der Kogel,
James W. Sayre,
William H. McBride,
Timothy D. Solberg
et al.
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1031-1037
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Simultaneous Inhibition of EGFR and PI3K Enhances Radiosensitivity in Human Breast Cancer
12 March 2012
Purpose: Mutations in the epidermal growth factor receptor (EGFR)/phosphoinositide 3-kinase (PI3K)/Akt signaling transduction pathway are common in cancer. This pathway is imperative to the radiosensi...
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Ping Li,
Qing Zhang,
Artour Torossian,
Zhao-bin Li,
Wen-cai Xu,
Bo Lu,
Shen Fu
et al.
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e391-e397
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Celecoxib Enhances the Radiosensitizing Effect of 7-Hydroxystaurosporine (UCN-01) in Human Lung Cancer Cell Lines
14 March 2012
Purpose: 7-Hydroxystaurosporine (UCN-01), a Chk1-specific inhibitor, showed promising in vitro and in vivo chemo- or radiosensitizing activity. However, there have been concerns about its limited ther...
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Young-Mee Kim,
In-Hye Jeong,
Hongryull Pyo
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e399-e407
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A Novel Peptide to Treat Oral Mucositis Blocks Endothelial and Epithelial Cell Apoptosis
14 March 2012
Purpose: No effective agents currently exist to treat oral mucositis (OM) in patients receiving chemoradiation for the treatment of head-and-neck cancer. We identified a novel 21–amino acid peptide de...
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Xiaoyan Wu,
Peili Chen,
Stephen T. Sonis,
Mark W. Lingen,
Ann Berger,
F. Gary Toback
et al.
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e409-e415
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| Physics Contributions |
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Author(s) |
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Evaluation of an Automatic Registration-Based Algorithm for Direct Measurement of Volume Change in Tumors
15 December 2011
Purpose: Assuming that early tumor volume change is a biomarker for response to therapy, accurate quantification of early volume changes could aid in adapting an individual patient’s therapy and lead ...
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Saradwata Sarkar,
Timothy D. Johnson,
Bing Ma,
Thomas L. Chenevert,
Peyton H. Bland,
Hyunjin Park,
Anne F. Schott,
Brian D. Ross,
Charles R. Meyer
et al.
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1038-1046
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Helical Volumetric Modulated Arc Therapy for Treatment of Craniospinal Axis
23 November 2011
Purpose: Volumetric modulated arc therapy (VMAT) can be used with multiple isocenters to provide an effective treatment of the craniospinal axis. Additional efficiency can be achieved by simultaneousl...
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James L. Bedford,
Young K. Lee,
Frank H. Saran,
Alan P. Warrington
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1047-1054
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