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Editorial Board
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CO2
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| Open Forum |
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Towards a need to a “biological Sokal risk” in the era of tyrosine kinase inhibitors in choosing front-line therapy in chronic myeloid leukemia
13 April 2012
The recent introduction and proven effectiveness of dasatinib (DAS) and nilotinib (NIL) in the front-line therapy of chronic myeloid leukemia (CML) together with the revolutionary results already giv...
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Fabio Stagno,
Paolo Vigneri,
Francesco Di Raimondo
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803
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| Guest Editorials |
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Adherence to treatment is a complex and multifaceted issue that can substantially alter the outcome of chronic myeloid leukemia patients treated with tyrosine kinase inhibitors
29 March 2012
Tyrosine kinase inhibitors have dramatically changed the therapeutic strategies for chronic myeloid leukemia (CML) patients and given most of them the opportunity to substantially improve their long-t...
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Massimo Breccia,
Fabio Efficace,
Giuliana Alimena
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804-805
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Cytogenetics in myelodysplastic syndromes: Old methods, new clues
01 May 2012
The identification of non-random chromosomal abnormalities by metaphase karyotyping is a cornerstone in the diagnostic work-up of patients affected by myelodysplastic syndromes (MDS). The demonstratio...
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Gian Matteo Rigolin,
Antonio Cuneo
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806-807
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A role for caspase inhibitors in differentiation therapy of myeloid leukaemia
25 April 2012
The paper by Chen-Deutch et al. 2012 describes an interesting way forward to the possible use of 1α,25-dihydroxyvitamin D3 (D3) in differentiation therapy of acute myeloid leukaemia (AML) by the comb...
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Geoffrey Brown,
Philip J. Hughes
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808-810
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The place of sideroblastic erythropoiesis in WHO 2008 classification of MDS; RCMD versus RCMD-RD as combined or a separate entity?
04 May 2012
The 2001 WHO classification of myeloid neoplasms divided refractory anemia (RA) of the myelodysplastic syndromes (MDS) to two types; those with dysplasia restricted to the erythroid lineage and those ...
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Yataro Yoshida
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811-812
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| Commentary |
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Progressive arterial occlusive disease (PAOD) and pulmonary arterial hypertension (PAH) as new adverse events of second generation TKIs in CML treatment: Who's afraid of the big bad wolf?
06 April 2012
The occurrence of side effects in chronic myeloid leukaemia (CML) patients treated with tyrosine kinase inhibitors (TKIs) seem to differ between agents and also the rate of haematologic and non-haemat...
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Massimo Breccia,
Fabio Efficace,
Giuliana Alimena
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813-814
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| Comments on Published Paper |
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Long term follow-up of Polycythemia Vera patients treated with imatinib mesylate
09 April 2012
Silver et al. recently described in this journal . Their study of the treatment of Polycythemia Vera with imatinib mesylate and kindly noted our earlier reports. The design of both studies was compara...
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C. Michael Jones
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815-816
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| Clinical Studies |
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Adherence to oral tyrosine kinase inhibitor therapies in chronic myeloid leukemia
27 February 2012
Abstract: Ensuring adherence to therapy is a challenge in chronic diseases, particularly in cancers such as chronic myeloid leukemia (CML), where there has been increased availability and use of oral ...
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Adam Gater,
Louise Heron,
Linda Abetz-Webb,
John Coombs,
Jeff Simmons,
François Guilhot,
Delphine Rea
et al.
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817-825
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Prognoses of MDS subtypes RARS, RCMD and RCMD-RS are comparable but cytogenetics separates a subgroup with inferior clinical course
03 May 2012
Abstract: In 2008, the WHO combined the former categories RCMD (refractory cytopenia with multilineage dysplasia) and RCMD-RS (ring sideroblasts ≥15%). We studied the clinical impact and genetic backg...
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Ulrike Bacher,
Wolfgang Kern,
Tamara Alpermann,
Susanne Schnittger,
Claudia Haferlach,
Torsten Haferlach
et al.
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826-831
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Will a peripheral blood (PB) sample yield the same diagnostic and prognostic cytogenetic data as the concomitant bone marrow (BM) in myelodysplasia?
26 April 2012
Abstract: In patients with myelodysplastic syndromes (MDS), chromosome anomalies are detected by conventional cytogenetic studies (CCS) and/or interphase fluorescence in situ hybridization (FISH) of b...
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Athena M. Cherry,
Marilyn L. Slovak,
Lynda J. Campbell,
Kathy Chun,
Virginie Eclache,
Detlef Haase,
Claudia Haferlach,
Barbara Hildebrandt,
Anwar M. Iqbal,
Suresh C. Jhanwar,
Kazuma Ohyashiki,
Francesc Sole,
Peter Vandenberghe,
Daniel L. VanDyke,
Yanming Zhang,
Gordon W. Dewald
et al.
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832-840
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Combination therapy with arsenic trioxide, all-trans retinoic acid, and chemotherapy in acute promyelocytic leukemia patients with various relapse risks
25 April 2012
Abstract: To improve the recovery rate of high-risk patients with acute promyelocytic leukemia (APL), we used all-trans retinoic acid (ATRA)/arsenic trioxide (ATO)/daunorubicin combination in remissio...
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Hongming Huang,
Yan Qin,
Ruirong Xu,
Xuefeng You,
Rong Teng,
Li Yang,
Mengqi Xu,
Hong Liu
et al.
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841-845
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CD105 and placental growth factor – Potent prognostic factors in childhood acute lymphoblastic leukaemia
12 April 2012
Abstract: The studies aimed at identifying a prognostic significance of angiogenesis-related factors: CD105 and placental growth factor (PlGF) in a course of acute lymphoblastic leukaemia (ALL). Resea...
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Patrycja Sujka-Kordowska,
Agnieszka Malinska,
Danuta Ostalska-Nowicka,
Maciej Zabel,
Michal Nowicki
et al.
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846-851
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A new recurrent chromosomal translocation t(3;11)(q13;q14) in myelodysplastic syndromes associated with overexpression of the ILDR1 gene
27 February 2012
Abstract: Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by ineffective hematopoiesis and an increased risk of evolution to acute myeloid leukemia (AML). In this s...
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Antonella Zagaria,
Luisa Anelli,
Nicoletta Coccaro,
Paola Casieri,
Angela Minervini,
Valentina Buttiglione,
Alessandra Ricco,
Giorgina Specchia,
Francesco Albano
et al.
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852-856
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Phase II study on combination therapy with CHOP-Zenapax for HTLV-I associated adult T-cell leukaemia/lymphoma (ATLL)
03 January 2012
Abstract: Adult T-cell leukaemia lymphoma (ATLL) is an aggressive T-cell malignancy caused by the human T-lymphotropic virus type-1 (HTLV-1) and is associated with a very poor prognosis. Combination c...
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M. Mansour Ceesay,
Estella Matutes,
Graham P. Taylor,
Paul Fields,
Jamie Cavenagh,
Sylwia Simpson,
Aloysius Ho,
Stephen Devereux,
Ghulam J. Mufti,
Antonio Pagliuca
et al.
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857-861
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Src, Akt, NF-κB, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia
16 May 2012
Abstract: BCR-ABL kinase has been observed to be potentially related to leukemic cell development. Adult patients with acute lymphoblastic leukemia (ALL) were evaluated to determine whether presence/a...
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José E. Vázquez-Franco,
Elba Reyes-Maldonado,
Jorge Vela-Ojeda,
Maria L. Domínguez-López,
Ruth A. Lezama
et al.
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862-867
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Obesity but not overweight increases the incidence and mortality of leukemia in adults: A meta-analysis of prospective cohort studies
30 January 2012
Abstract: The main objectives of the present meta-analysis of prospective cohort studies were to evaluate the role of obesity on the incidence and mortality of leukemia in adults. Obesity was associat...
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Jorge J. Castillo,
John L. Reagan,
Randall R. Ingham,
Michael Furman,
Samir Dalia,
Basma Merhi,
Saed Nemr,
Ali Zarrabi,
Joanna Mitri
et al.
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868-875
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High expression of hematopoietic cell specific Lyn substrate-1 (HS1) predicts poor survival of B-cell chronic lymphocytic leukemia patients
14 February 2012
Abstract: B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in adults in western countries. HS1 protein regulates leukemic cell migration and homing, and can indirectly promote d...
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Aleksandra Butrym,
Miroslaw Majewski,
Justyna Dzietczenia,
Kazimierz Kuliczkowski,
Grzegorz Mazur
et al.
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876-880
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Expression of soluble HLA-G in multiple myeloma patients and patients with renal failure
15 March 2012
Abstract: Human lymphocyte antigen-G (HLA-G) is an immunosuppressive molecule that induces functional silencing of immune component cells and can be responsible for immunosuppression in patients with ...
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Paulina Wlasiuk,
Anna Stec,
Agnieszka Piechnik,
Wioletta Kaminska,
Anna Dmoszynska,
Andrzej Ksiazek,
Krzysztof Giannopoulos
et al.
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881-883
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| Laboratory Studies |
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The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells
30 April 2012
Abstract: Caspase function is known to be essential for cell death by apoptosis, but it is now increasingly recognized that these proteases also play important roles in other cellular events. Here we ...
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Xiangwen Chen-Deutsch,
Andrzej Kutner,
Jonathan S. Harrison,
George P. Studzinski
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884-888
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Establishment and characterization of a new human acute myelomonocytic leukemia cell line JIH-3
16 February 2012
Abstract: Here, a new acute myelomonocytic leukemia (AMML) cell line, JIH-3, is reported, and its biological characteristics are described. JIH-3 cells were maintained without any cytokines for 27 mon...
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Jinlan Pan,
Yongquan Xue,
Suning Chen,
Huiying Qiu,
Chunxiao Wu,
Hui Jiang,
Qian Wang,
Jun Zhang,
Suxiao Bai,
Yafang Wu,
Yong Wang,
Juan Shen
et al.
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889-894
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Epigenetic regulation of PRAME in acute myeloid leukemia is different compared to CD34+ cells from healthy donors: Effect of 5-AZA treatment
16 April 2012
Abstract: PRAME is a tumor associated antigen (TAA) of particular interest since it is widely expressed by lymphoid and myeloid malignancies. Several studies have associated high PRAME RNA levels with...
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S. Gutierrez-Cosío,
L. de la Rica,
E. Ballestar,
C. Santamaría,
L.I. Sánchez-Abarca,
T. Caballero-Velazquez,
B. Blanco,
C. Calderón,
C. Herrero-Sánchez,
S. Carrancio,
L. Ciudad,
C. Cañizo,
J.F. San Miguel,
J.A. Pérez-Simón
et al.
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895-899
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Assessing signaling pathways associated with in vitro resistance to cytotoxic agents in AML
23 April 2012
Abstract: This study uses single cell network profiling (SCNP) to characterize biological pathways associated with in vitro resistance or sensitivity to chemotherapeutics commonly used in acute myeloi...
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David B. Rosen,
James A. Cordeiro,
Aileen Cohen,
Norman Lacayo,
Donna Hogge,
Rachael E. Hawtin,
Alessandra Cesano
et al.
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900-904
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Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL
19 March 2012
Abstract: To identify microRNAs regulated by oncogenic Notch signaling, we performed microarray-based miRNA profiling of T-cell acute lymphoblastic leukemia (T-ALL) cells before and after treatment wi...
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Samuel Gusscott,
Florian Kuchenbauer,
R. Keith Humphries,
Andrew P. Weng
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905-911
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The dual PI3K and mTOR inhibitor NVP-BEZ235 exhibits anti-proliferative activity and overcomes bortezomib resistance in mantle cell lymphoma cells
07 May 2012
Abstract: Mantle cell lymphoma (MCL) is one of the most difficult B-cell lymphomas to be treated. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is constitut...
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Areumnuri Kim,
Sunhoo Park,
Jung-Eun Lee,
Won-Suk Jang,
Sun-Joo Lee,
Hye Jin Kang,
Seung-Sook Lee
et al.
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912-920
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Azacitidine differentially affects CD4pos T-cell polarization in vitro and in vivo in high risk myelodysplastic syndromes
16 April 2012
Abstract: CD4pos T-cell subsets play a role in myelodysplastic syndromes (MDS) pathogenesis and may be affected upon 5-azacitidine (Aza) treatment. Aza enhanced human TH1 frequencies in vitro but not ...
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Hetty J. Bontkes,
Jurjen M. Ruben,
Canan Alhan,
Theresia M. Westers,
Gert J. Ossenkoppele,
Arjan A. van de Loosdrecht
et al.
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921-930
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| Brief Communications |
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Downregulation of IRS2 in myelodysplastic syndrome: A possible role in impaired hematopoietic cell differentiation
02 April 2012
Abstract: Insulin receptor substrate 2 (IRS2) is an adaptor protein that associates with the receptor of erythropoietin, insulin-like growth factor 1 and thrombopoietin; however, its role is not known...
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João Agostinho Machado-Neto,
Patricia Favaro,
Mariana Lazarini,
Adriana da Silva Santos Duarte,
Leticia Fröhlich Archangelo,
Irene Lorand-Metze,
Fernando Ferreira Costa,
Sara Teresinha Olalla Saad,
Fabiola Traina
et al.
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931-935
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Additional aberrations of the ETV6 and RUNX1 genes have no prognostic impact in 229 t(12;21)(p13;q22)-positive B-cell precursor acute lymphoblastic leukaemias treated according to the NOPHO-ALL-2000 protocol
23 April 2012
The ETV6/RUNX1 fusion, which is the molecular consequence of the cytogenetically cryptic t(12;21)(p13;q22), is present in approximately 25% of paediatric B-cell precursor acute lymphoblastic leukaemia...
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Gisela Barbany,
Mette K. Andersen,
Kirsti Autio,
Georg Borgström,
Lucia Cavalier Franco,
Irina Golovleva,
Sverre Heim,
Kristina Heinonen,
Randi Hovland,
Bertil Johansson,
Johann H. Johannsson,
Eigil Kjeldsen,
Ann Nordgren,
Lars Palmqvist,
Erik Forestier,
on behalf of the Nordic Society of Paediatric Haematology and Oncology (NOPHO), the Swedish Cytogenetic Leukaemia Study Group (SCLSG) and the NOPHO Leukaemia Cytogenetic Study Group (NLCSG)
et al.
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936-938
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| E-page Letters (available online only) |
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Acute myeloid leukemia with minimal differentiation: Unusual cytogenetics, morphology, phenotype and clinical course
06 April 2012
The diagnosis of acute myeloid leukemia (AML) requires the identification of more than 20% of the blasts in the bone marrow or the peripheral blood, with the expression of myeloid markers, such as CD1...
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Peter Rohon,
Radka Nedomova,
Ivana Prekopova,
Jaromir Hubacek,
Milena Holzerova,
Zuzana Pikalova,
Patrik Flodr,
Tomas Papajik,
Karel Indrak,
Marie Jarosova
et al.
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e133-e136
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Hypersensitivity to alkylation treatment of primary fibroblasts from patients with therapy-related myeloid neoplasms
05 April 2012
Therapy-related myeloid neoplasms (t-MNs) constitute a distinct clinical syndrome arising after cytotoxic treatments for a primary, often malignant disorder. In the majority of cases, previous treatme...
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Julia Rankl,
Karin Flicker,
Angelika Valentin,
Michael Horn,
Selman Uranüs,
Andrea Groselj-Strele,
Werner Emberger,
Heinz Sill
et al.
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e137-e139
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New complex chromosome abnormalities in multiple myeloma associated with a poor prognosis: A case report
13 April 2012
Multiple myeloma (MM) is a malignant proliferation of monoclonal plasma cells characterized by its accumulation in the bone marrow, production of excessive monoclonal immunoglobulin (M protein) in ser...
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Agnes C. Fett-Conte,
Andréa B. Carvalho-Salles,
Cristina B. Vendrame,
Patrícia Pedrassa,
Paula C. Freitas,
Marileila Varella-Garcia
et al.
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e140-e142
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ALK-positive anaplastic large cell lymphoma with TPM3-ALK translocation
16 May 2012
Anaplastic large cell lymphoma (ALCL) is a T cell lymphoma consisting of large cells that express CD30 . Anaplastic lymphoma kinase (ALK) is expressed in 50–80% of ALCLs, with a higher frequency of AL...
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Saeam Shin,
Juwon Kim,
Sun Och Yoon,
Yu Ri Kim,
Kyung-A. Lee
et al.
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e143-e145
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Neutrophilic panniculitis following azacitidine treatment for myelodysplastic syndromes
09 April 2012
Myelodysplastic syndromes (MDS) comprise a heterogeneous group of clonal hematopoietic stem cell disorders. The clinical spectrum ranges from a stable condition to manifestation of entities with incre...
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In-Ho Kim,
Jae-Ho Youn,
Seung-Hwan Shin,
Seung-Ah Yahng,
Sung-Eun Lee,
Jae-Cheol Kwon,
Dong-Gun Lee,
Kyung-Shin Park,
Moon-Hyung Choi,
Seung-Eun Jung,
Yoo-Jin Kim
et al.
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e146-e148
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Mycosis fungoides with testicular involvement: A rare phenomenon
07 May 2012
A 76-year-old Caucasian male was referred to Indiana University Melvin and Bren Simon Cancer Center (IUSCC) in July 2009 after a skin biopsy demonstrated mycosis fungoides. The histopathology was revi...
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Muhammad Rizwan Khawaja,
Lawrence Mark,
Riley E. Alexander,
Mehdi Nassiri,
Jose Azar
et al.
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e149-e152
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Stevens-Johnson syndrome after treatment with bendamustine
05 April 2012
Rituximab, the anti-CD20 monoclonal antibody, has changed the therapeutic landscape for patients with non-Hodgkin's lymphoma (NHL) either as a single agent or, particularly, in combination with chemot...
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Matteo Lambertini,
Lucia Del Mastro,
Giovanni Gardin,
Alessia Levaggi,
Claudia Bighin,
Sara Giraudi,
Paolo Pronzato
et al.
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e153-e154
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Extranodal marginal zone lymphoma of the CNS arising after a long-standing history of atypical white matter disease
20 April 2012
In February 2009 a 39 year old female patient with a long standing history of atypical white matter lesions mimicking multiple sclerosis was admitted to the Department of Neurology, Budapest, due to d...
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Ana-Iris Schiefer,
Ildiko Vastagh,
Maria Judit Molnar,
Daniel Bereczki,
György Varallyay,
Beata Deak,
Judit Csomor,
Eszter Turanyi,
Gabor G. Kovacs,
Leonhard Müllauer
et al.
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e155-e157
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