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Tools for the identification of bioactives impacting the metabolic syndrome: screening of a botanical extract library using subcutaneous and visceral human adipose-derived stem cell-based assays
05 May 2011
Abstract: Plant extracts continue to represent an untapped source of renewable therapeutic compounds for the treatment and prevention of illnesses including chronic metabolic disorders. With the incre...
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Benjamin M. Buehrer,
David J. Duffin,
Y. Renee Lea-Currie,
David Ribnicky,
Ilya Raskin,
Jacqueline M. Stephens,
William T. Cefalu,
Jeffrey M. Gimble
et al.
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519-525
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Dietary supplementation with high dose of epigallocatechin-3-gallate promotes inflammatory response in mice
20 June 2011
Abstract: Epigallocatechin-3-gallate (EGCG) from green tea has been indicated to have anti-inflammatory activity. However, most of the evidence is in vitro studies in which EGCG is often added at leve...
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Munkyong Pae,
Zhihong Ren,
Mohsen Meydani,
Fu Shang,
Donald Smith,
Simin Nikbin Meydani,
Dayong Wu
et al.
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526-531
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Estrogen status alters tissue distribution and metabolism of selenium in female rats
20 June 2011
Abstract: A reported association between estrogen and selenium status may be important in the regulation of selenium metabolism. In this study, the effect of estrogen status on the metabolism of orall...
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Xiaodong Zhou,
Anne M. Smith,
Mark L. Failla,
Kristina E. Hill,
Zhongtang Yu
et al.
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532-538
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Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids
20 July 2011
Abstract: The present study highlights the important association between lipid alterations and differentiation/apoptotic responses in human colon differentiating (FHC) and nondifferentiating (HCT-116)...
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Jiřina Hofmanová,
Miroslav Ciganek,
Josef Slavík,
Alois Kozubík,
Lenka Stixová,
Alena Vaculová,
Ladislav Dušek,
Miroslav Machala
et al.
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539-548
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Chinese red yeast rice attenuates the development of angiotensin II-induced abdominal aortic aneurysm and atherosclerosis
18 July 2011
Abstract: Objective: Abdominal aortic aneurysm (AAA) is a chronic vascular disease characterized by medial degradation and inflammation. No medical approaches have been validated for treating AAA, and...
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Xiaojie Xie,
Yifan Wang,
Songzhao Zhang,
Guidi Zhang,
Yinchuan Xu,
Honghao Bi,
Alan Daugherty,
Jian-an Wang
et al.
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549-556
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Anti-atherogenic and anti-angiogenic activities of polyphenols from propolis
18 July 2011
Abstract: Propolis is a polyphenol-rich resinous substance extensively used to improve health and prevent diseases. The effects of polyphenols from different sources of propolis on atherosclerotic les...
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Julio Beltrame Daleprane,
Vanessa da Silva Freitas,
Alejandro Pacheco,
Martina Rudnicki,
Luciane Aparecida Faine,
Felipe Augusto Dörr,
Masaharu Ikegaki,
Luis Antonio Salazar,
Thomas Prates Ong,
Dulcinéia Saes Parra Abdalla
et al.
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557-566
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Acute inflammation plays a limited role in the regulation of adipose tissue COL1A1 protein abundance
20 July 2011
Abstract: Obesity is an inflammatory condition that is also associated with increased extracellular matrix (ECM) gene expression. However, a direct link between adipose tissue inflammation and ECM gen...
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Venkata J. Adapala,
Sunday A. Adedokun,
Robert V. Considine,
Kolapo M. Ajuwon
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567-572
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Equol production changes over time in postmenopausal women
20 July 2011
Abstract: Equol (EQ) is produced by intestinal bacteria from the soy isoflavone daidzein (DE) in 30%–60% of the population and is believed to provide benefits from soy intake. A robust EQ status defin...
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Adrian A. Franke,
Jennifer F. Lai,
Brunhild M. Halm,
Ian Pagano,
Naoko Kono,
Wendy J. Mack,
Howard N. Hodis
et al.
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573-579
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Trans-10, cis-12 conjugated linoleic acid decreases de novo lipid synthesis in human adipocytes
20 July 2011
Abstract: Conjugated linoleic acid (CLA) reduces adiposity in vivo. However, mechanisms mediating these changes are unclear. Therefore, we treated cultures of human adipocytes with trans-10, cis-12 (1...
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Thomas Obsen,
Nils J. Faergeman,
Soonkyu Chung,
Kristina Martinez,
Semone Gobern,
Olivier Loreau,
Martin Wabitsch,
Susanne Mandrup,
Michael McIntosh
et al.
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580-590
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The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma
20 July 2011
Abstract: Previous studies suggested that curcumin is a potential agent against glioblastomas (GBMs). However, the in vivo efficacy of curcumin in gliomas remains not established. In this work, we exa...
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Alfeu Zanotto-Filho,
Elizandra Braganhol,
Maria Isabel Edelweiss,
Guilherme A. Behr,
Rafael Zanin,
Rafael Schröder,
André Simões-Pires,
Ana Maria Oliveira Battastini,
José Cláudio Fonseca Moreira
et al.
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591-601
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Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells
18 July 2011
Abstract: Eotaxin-3 (CCL-26), a potent chemokine for eosinophil recruitment and contributing significantly to the pathogenesis of asthma, is secreted by lung epithelial cells in response to T helper 2...
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Yun Wang,
Michelle Moreland,
James G. Wagner,
Bruce N. Ames,
Beate Illek,
David B. Peden,
Qing Jiang
et al.
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602-608
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A Mediterranean-style low-glycemic-load diet increases plasma carotenoids and decreases LDL oxidation in women with metabolic syndrome
20 July 2011
Abstract: Thirty-five women with metabolic syndrome and high plasma low-density lipoprotein (LDL) cholesterol (≥100 mg/dl) participated in a dietary intervention consisting of a Mediterranean-style lo...
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Jacqueline Barona,
Jennifer J. Jones,
Rachel E. Kopec,
Michael Comperatore,
Catherine Andersen,
Steven J. Schwartz,
Robert H. Lerman,
Maria Luz Fernandez
et al.
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609-615
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Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men
20 July 2011
Abstract: Our previous study with docosahexaenoic acid (DHA) supplementation to hypertriglyceridemic men showed that DHA reduced several risk factors for cardiovascular disease, including the plasma c...
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Kevin Dawson,
Ling Zhao,
Yuriko Adkins,
Madhuri Vemuri,
Raymond L. Rodriguez,
Jeffrey P. Gregg,
Darshan S. Kelley,
Daniel H. Hwang
et al.
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616-621
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Nonalcoholic fatty liver disease is associated with an altered hepatocyte microRNA profile in LDL receptor knockout mice
18 July 2011
Abstract: MicroRNAs modulate processes associated with cell cycle control and differentiation. Here we explored the potential of microRNAs in the modulation of hepatic lipid metabolism and the develop...
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Menno Hoekstra,
Ronald J. van der Sluis,
Johan Kuiper,
Theo J.C. Van Berkel
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622-628
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The effects of transformation and ZnT-1 silencing on zinc homeostasis in cultured cells
20 July 2011
Abstract: We have previously demonstrated that reducing the availability of zinc with the extracellular chelator diethylenetriaminepentaacetic acid (DTPA) promotes efflux of 65Zn from rat primary hepa...
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Kavitha Sankavaram,
Hedley C. Freake
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629-634
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Cytosine methylation in miR-153 gene promoters increases the expression of holocarboxylase synthetase, thereby increasing the abundance of histone H4 biotinylation marks in HEK-293 human kidney cells
18 July 2011
Abstract: Holocarboxylase synthetase (HCS) plays an essential role in catalyzing the biotinylation of carboxylases and histones. Biotinylated carboxylases are important for the metabolism of glucose, ...
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Baolong Bao,
Rocio Rodriguez-Melendez,
Janos Zempleni
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635-639
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Continuous intake of a high-fat diet beyond one generation promotes lipid accumulation in liver and white adipose tissue of female mice
20 July 2011
Abstract: Lipid metabolism in a child may be altered when the mother has a high-fat diet (HFD), but it is unclear whether the lipid metabolism of future offspring (grandchildren) is also changed under...
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Mariko Takasaki,
Taro Honma,
Miyuki Yanaka,
Kenta Sato,
Nahoko Shinohara,
Junya Ito,
Yurie Tanaka,
Tsuyoshi Tsuduki,
Ikuo Ikeda
et al.
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640-645
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Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells
18 July 2011
Abstract: Capsaicin is a pungent ingredient in chili red peppers and has been linked to suppression of growth in various cancer cells. However, the underlying mechanism(s) by which capsaicin induces g...
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Seong-Ho Lee,
Raphael L. Richardson,
Roderick H. Dashwood,
Seung Joon Baek
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646-655
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Quercetin accumulates in nuclear structures and triggers specific gene expression in epithelial cells
22 July 2011
Abstract: Quercetin is a flavonol modifying a number of cell processes in different cell lines. Here, we present evidence that nonconjugated quercetin enters cells possibly via organic anion transport...
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George Notas,
Artemisia-Phoebe Nifli,
Marilena Kampa,
Vassiliki Pelekanou,
Vasileia-Ismini Alexaki,
Panayiotis Theodoropoulos,
Joseph Vercauteren,
Elias Castanas
et al.
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656-666
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Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs
01 August 2011
Abstract: Previous studies have shown that an increased intake of dietary flavonoids is associated with a decreased risk of cardiovascular diseases (CVDs). PDGF is a major mitogen for vascular smooth ...
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Huey-Ming Lo,
Min-Wen Wu,
Shiow-Lin Pan,
Chieh-Yu Peng,
Pi-Hui Wu,
Wen-Bin Wu
et al.
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667-678
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Effects of soy protein on alcoholic liver disease in rats undergoing ethanol withdrawal
03 August 2011
Abstract: Objective: This investigation attempted to clarify the effects of soy protein on alcoholic liver disease (ALD) in rats undergoing ethanol withdrawal. Methods: Alcoholic liver disease was ind...
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Hsin-Yi Yang,
Hsiao-Shan Lin,
Jane C.J. Chao,
Yi-Wen Chien,
Hsiang-Chi Peng,
Jiun-Rong Chen
et al.
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679-684
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Linoleic acid increases monocyte chemotaxis and adhesion to human aortic endothelial cells through protein kinase C- and cyclooxygenase-2-dependent mechanisms
16 August 2011
Abstract: The effects of polyunsaturated n-6 linoleic acid on monocyte–endothelial interactions were investigated with particular emphasis on the expression of platelet/endothelial cell adhesion molec...
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Nuria Matesanz,
Victoria Jewhurst,
Elisabeth R. Trimble,
Ann McGinty,
Daphne Owens,
Gerald H. Tomkin,
Lesley A. Powell
et al.
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685-690
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