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Regulators of protein metabolism are affected by cyclical nutritional treatments with diets varying in protein and energy content
03 February 2012
Sourour Boussaid-Om Ezzine, Sonia Métayer-Coustard, Anne Collin, Nicole Rideau, Christine Leterrier, Isabelle Bouvarel, Iban Seiliez, Sophie Tesseraud
Abstract: There is evidence that the E3 ubiquitin ligases muscle ring finger-1 (MuRF1) and atrogin-1, which mediate the ubiquitination of certain proteins and thereby their proteolysis, are regulated ...
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PPARγ as a molecular target of EPA anti-inflammatory activity during TNF-α-impaired skeletal muscle cell differentiation
03 February 2012
Peter Magee, Stephen Pearson, Jayde Whittingham-Dowd, Jeremy Allen
Abstract: Activated skeletal muscle satellite cells facilitate muscle repair or growth through proliferation, differentiation and fusion into new or existing myotubes. Elevated levels of the proinflam...
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Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10
30 January 2012
Ming-Hsun Wu, Yo-Ting Tsai, Kuo-Tai Hua, Kun-Che Chang, Min-Liang Kuo, Ming-Tsan Lin
Abstract: Uptake of docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) improves the treatment of cancer and reduces tumor-associated macrophage count. However, the mechanism of this relationship i...
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Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
27 January 2012
Yuhan Tang, Jian Xu, Wei Qu, Xiaolin Peng, Peng Xin, Xuefeng Yang, Chenjiang Ying, Xiufa Sun, Liping Hao
Abstract: Objective: Senescence of vascular cells contributes to the development of cardiovascular diseases and the overall aging. This study was undertaken to investigate the effects of resveratrol (...
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The soybean peptide aglycin regulates glucose homeostasis in type 2 diabetic mice via IR/IRS1 pathway
25 January 2012
Jingli Lu, Ying Zeng, Wenrui Hou, Shasha Zhang, Lulu Li, Xiang Luo, Wei Xi, Zhengwang Chen, Ming Xiang
Abstract: It has been previously reported that aglycin, a natural bioactive peptide isolated from soybean, is stable in digestive enzymes and has an antidiabetic potential. With a view to explore the ...
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