Current Issue June 2012, Vol. 48, No. 9

EJC News Focus

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Advances in the treatment of early breast cancer have revolutionised the outlook for many patients. But an important minority - around one in three - still progress to the advanced stage, which is treatable, but almost never curable. Women and men with advanced breast cancer have an illness associated with significant symptoms and one for which, in contrast to the early setting, there are few recognised therapeutic standards. An international, multidisciplinary group has now produced the first consensus guidelines, and they were presented at the European Breast Cancer Conference (Vienna, Austria; 21-24 March 2012).

Lead author Fatima Cardoso (Champalimaud Cancer Center, Lisbon, Portugal) explains why she strongly believes that widespread implementation of these guidelines will lead to better survival outcomes in advanced breast cancer.

Issue Highlights

  • Type 2 diabetes mellitus and colorectal cancer: Meta-analysis on sex-specific differences
    June 2012 (Vol. 48 | No. 9 | Pages 1269-1282)

    Heike U. Krämer, Ben Schöttker, Elke Raum, Hermann Brenner

  • Lung cancer in never smokers – A review
    June 2012 (Vol. 48 | No. 9 | Pages 1299-1311)

    Sébastien Couraud, Gérard Zalcman, Bernard Milleron, Franck Morin, Pierre-Jean Souquet

  • Long term renal toxicity of ifosfamide in adult patients – 5year data
    June 2012 (Vol. 48 | No. 9 | Pages 1326-1331)

    James K. Farry, Carlos D. Flombaum, Sheron Latcha

  • Mature results of a phase II trial on individualised accelerated radiotherapy based on normal tissue constraints in concurrent chemo-radiation for stage III non-small cell lung cancer
    21 May 2012

    Angela van Baardwijk, Bart Reymen, Stofferinus Wanders, Jacques Borger, Michel Öllers, Anne-Marie C. Dingemans, Gerben Bootsma, Wiel Geraedts, Cordula Pitz, Ragnar Lunde, Frank Peters, Philippe Lambin, Dirk De Ruysscher

  • NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality
    21 May 2012

    Roger Stupp, Eric T. Wong, Andrew A. Kanner, David Steinberg, Herbert Engelhard, Volkmar Heidecke, Eilon D. Kirson, Sophie Taillibert, Frank Liebermann, Vladimir Dbalý, Zvi Ram, J. Lee Villano, Nikolai Rainov, Uri Weinberg, David Schiff, Lara Kunschner, Jeffrey Raizer, Jerome Honnorat, Andrew Sloan, Mark Malkin, Joseph C. Landolfi, Franz Payer, Maximilian Mehdorn, Robert J. Weil, Susan C. Pannullo, Manfred Westphal, Martin Smrcka, Lawrence Chin, Herwig Kostron, Silvia Hofer, Jeffrey Bruce, Rees Cosgrove, Nina Paleologous, Yoram Palti, Philip H. Gutin

  • Higher prevalence of sexual dysfunction in colon and rectal cancer survivors compared with the normative population: A population-based study
    21 May 2012

    B.L. Den Oudsten, M.J. Traa, M.S.Y. Thong, H. Martijn, I.H.J.T. De Hingh, K. Bosscha, L.V. van de Poll-Franse

  • Cisplatin and gemcitabine administered every two weeks in patients with locally advanced or metastatic urothelial carcinoma and impaired renal function
    18 May 2012

    Rafael Morales-Barrera, Joaquim Bellmunt, Cristina Suárez, Claudia Valverde, Marta Guix, Cesar Serrano, Manuel Gallén, Joan Carles

  • Quality-of-life among head and neck cancer survivors at one year after treatment – A systematic review
    14 May 2012

    W.K.W. So, R.J. Chan, D.N.S. Chan, B.G.M. Hughes, S.Y. Chair, K.C. Choi, C.W.H. Chan

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New: Hormone Receptor Positive Breast Cancer Resource Centre

For all the latest research on Hormone Receptor Positive Breast Cancer, including original research articles and video interviews with leading researchers, visit our new resource centre at www.ejcancer-breast.com, edited by Professor Robert E. Coleman.

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A Eulogy for Dr Stefano Ciatto

On May 4th 2012 the world of cancer screening and imaging lost one of its most credible clinicians and outstanding researchers in a fatal car crash, in Italy, and we lost a friend and much admired colleague.

Stefano was a free-spirited person who worked tirelessly in cancer screening practice, teaching and research; he was a brilliant, courageous man who was strong enough to challenge the status quo and to oppose any abuse of power. At the same time he was a generous and perceptive human being, capable of touching people’s lives in the kindest ways, even from a distance.

Stefano was born in Florence in 1949. During high school and university years he was a bright student with a great passion for knowledge and for music. After graduating in medicine in 1973, he dedicated his time to research and care of cancer patients, at the University of Florence, and was subsequently appointed Associate Professor; in the early ‘80s he moved to the Center for Cancer Prevention of Florence (CSPO, now ISPO) where he entirely dedicated himself to cancer screening and detection, mostly breast and prostate. More recently he moved to Verona, where he continued working in breast screening and imaging research.

We have been fortunate to have known Stefano and to have collaborated with him in research for many years, and we thank him for supporting us in the quest for scientific evidence. He had an inquisitive mind and was skilled in investigating all aspects of cancer diagnosis, from disproving the proposed role of thermography in the 1970’s, to pioneering studies in breast tomosynthesis in 2012, his research productivity has been tremendous (more than 300 peer reviewed publications). Teaching was one of Stefano’s passions, and the majority of Italian radiologists, and many other European breast specialists, with interest in breast cancer diagnosis, have received training by Stefano at some stage. Stefano was also one of the longest serving members of the Editorial Board of The Breast.

Stefano was not only a great scientist and teacher, he was also a loving father, and we offer our condolences to his family. Amongst his many talents, he played the guitar, was a gifted sketch-artist, fiction writer and theatre actor. We would like to remember him as a man who opened his heart to life, who lived a genuine and full life with passion and enthusiasm. We pay tribute to Stefano’s major scientific contributions that have influenced breast cancer imaging practice and thank him for having given much of his time to helping others. Stefano, our friend, we will miss you – rest in peace.

Nehmat Houssami (Sydney, Australia) & Marco Rosselli Del Turco (Rome, Italy)

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European Journal of Cancer Cancer (including EJC Supplements) is an international multidisciplinary oncology journal which publishes original research, editorial comments, review articles and news on basic and preclinical research, translational oncology, clinical oncology (medical, paediatric, radiation, surgical), and cancer epidemiology and prevention. More

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