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Hair Cortisol Level as a Biomarker for Altered Hypothalamic-Pituitary-Adrenal Activity in Female Adolescents with Posttraumatic Stress Disorder After the 2008 Wenchuan Earthquake
03 February 2012
Hongrong Luo, Xun Hu, Xiang Liu, Xiaohong Ma, Wanjun Guo, Changjian Qiu, Yingcheng Wang, Qiang Wang, Xiaowei Zhang, Wei Zhang, Gregory Hannum, Kang Zhang, Xiehe Liu, Tao Li
Background: The present study evaluated the accumulated changes in hair cortisol levels of patients with posttraumatic stress disorder (PTSD) attributed to the 2008 Wenchuan earthquake in China. Metho...
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Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial
02 February 2012
Carlos A. Zarate, Nancy E. Brutsche, Lobna Ibrahim, Jose Franco-Chaves, Nancy Diazgranados, Anibal Cravchik, Jessica Selter, Craig A. Marquardt, Victoria Liberty, David A. Luckenbaugh
Background: Currently, no pharmacological treatments for bipolar depression exist that exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that intravenous admini...
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Association of COL25A1 with Comorbid Antisocial Personality Disorder and Substance Dependence
02 February 2012
Dawei Li, Hongyu Zhao, Henry R. Kranzler, David Oslin, Raymond F. Anton, Lindsay A. Farrer, Joel Gelernter
Background: Antisocial personality disorder (ASPD) is a psychiatric disorder characterized by a long-term pattern of manipulating, exploiting, or violating the rights of others. Methods: Subjects asce...
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Dopamine Release in Chronic Cannabis Users: A [11C]Raclopride Positron Emission Tomography Study
30 January 2012
Nina B.L. Urban, Mark Slifstein, Judy L. Thompson, Xiaoyan Xu, Ragy R. Girgis, Sonia Raheja, Margaret Haney, Anissa Abi-Dargham
Background: Low striatal dopamine 2/3 receptor (D2/3) availability and low ventrostriatal dopamine (DA) release have been observed in alcoholism and cocaine and heroin dependence. Less is known about ...
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Increasing Histone Acetylation in the Hippocampus-Infralimbic Network Enhances Fear Extinction
30 January 2012
James M. Stafford, Jonathan D. Raybuck, Andrey E. Ryabinin, K. Matthew Lattal
Background: A key finding from recent studies of epigenetic mechanisms of memory is that increasing histone acetylation after a learning experience enhances memory consolidation. This has been demonst...
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