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Editorial Board
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What's behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance
09 April 2012
Successful application of antibiotic therapy in the critically ill requires not only timely administration of an agent of appropriate spectrum but the provision of adequate drug concentrations at the ...
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Andrew A. Udy,
Jason A. Roberts,
Jan J. De Waele,
David L. Paterson,
Jeffrey Lipman
et al.
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455-457
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| Reviews |
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Cytosine deoxyribonucleoside anti-HIV analogues: a small chemical substitution allows relevant activities
24 January 2012
Abstract: The search for new nucleoside analogue compounds targeting the virally encoded reverse transcriptase was developed by modifying the nucleoside structure to create inhibitor compounds. In thi...
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Francesco Scaglione,
Liberato Berrino
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458-463
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Invasive fungal infections in patients with cancer in the Intensive Care Unit
15 February 2012
Abstract: Invasive fungal infections (IFIs) have emerged as a major cause of morbidity and mortality amongst critically ill patients. Cancer patients admitted to the Intensive Care Unit (ICU) have mul...
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Nikolaos V. Sipsas,
Dimitrios P. Kontoyiannis
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464-471
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Prevalence and analysis of microbiological factors associated with phenotypic heterogeneous resistance to carbapenems in Acinetobacter baumannii
26 March 2012
Abstract: The objectives of this study were to determine the prevalence of Acinetobacter baumannii with phenotypic heterogeneous resistance (PHR) to carbapenems (colonies inside the halo of inhibition...
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Felipe Fernández Cuenca,
Mª del Carmen Gómez Sánchez,
Francisco Javier Caballero-Moyano,
Jordi Vila,
Luis Martínez-Martínez,
Germán Bou,
Jesús Rodríguez Baño,
Alvaro Pascual
et al.
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472-477
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Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature
25 April 2012
Abstract: By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as an antibiotic with a novel feature. Nybomycin is active against quinolone-resistant Staphylococcus a...
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Keiichi Hiramatsu,
Masayuki Igarashi,
Yuh Morimoto,
Tadashi Baba,
Maya Umekita,
Yuzuru Akamatsu
et al.
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478-485
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gyrA/B fluoroquinolone resistance allele profiles amongst Mycobacterium tuberculosis isolates from mainland China
23 April 2012
Abstract: Fluoroquinolones are important second-line drugs for the treatment of tuberculosis. A comprehensive profile of resistance mutation patterns of DNA gyrase, the major target of fluoroquinolone...
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Quanxin Long,
Weimin Li,
Qinglin Du,
Yuhong Fu,
Qian Liang,
Hairong Huang,
Jianping Xie
et al.
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486-489
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Trending 7 years of in vitro activity of tigecycline and comparators against Gram-positive and Gram-negative pathogens from the Asia-Pacific region: Tigecycline Evaluation Surveillance Trial (TEST) 2004–2010
25 April 2012
Abstract: A total of 10948 clinical isolates was collected throughout the Asia-Pacific region as part of the Tigecycline Evaluation Surveillance Trial (TEST) during 2004–2010, consisting of 7549 Gram-...
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Stephen P. Hawser,
Samuel K. Bouchillon,
Meredith Hackel,
Minjun Chen,
Eui-Chong Kim
et al.
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490-495
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Bactericidal activity against meticillin-resistant Staphylococcus aureus of a novel eukaryotic therapeutic recombinant antimicrobial peptide
23 April 2012
Abstract: Antimicrobial peptides (AMPs) are one of several potential antibacterial agents in the current era of antibiotics facing severe challenges. In this study, the bactericidal activity and stabi...
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Qingtian Li,
Jiewen Huang,
Hongxiong Guo,
Xiaokui Guo,
Yongzhang Zhu,
Ke Dong
et al.
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496-499
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Anti-anaerobic activity of a new β-lactamase inhibitor NXL104 in combination with β-lactams and metronidazole
23 April 2012
Abstract: NXL104 is a new β-lactamase inhibitor (BLI) that inhibits class A and class C β-lactamase enzymes. In this study, the activity of NXL104 in combination with the third-generation cephalospori...
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L.J. Dubreuil,
S. Mahieux,
C. Neut,
C. Miossec,
J. Pace
et al.
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500-504
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Penetration of moxifloxacin into liver tissue
23 April 2012
Abstract: Moxifloxacin is considered for treatment of pyogenic liver abscesses as well as antibiotic prophylaxis in the case of hepatobiliary interventions. The aim of this study was to provide data o...
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Christoph Justinger,
Martin K. Schilling,
Martin G. Kees,
Anne Kauffels,
Katrin Hirschmann,
Berit Kopp,
Frieder Kees,
Otto Kollmar
et al.
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505-509
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Posaconazole plasma concentrations and invasive mould infections in patients with haematological malignancies
05 April 2012
Abstract: Posaconazole (PCZ) is a triazole antifungal agent that has broad activity against pathogenic fungi and is increasingly used for prophylaxis and treatment of invasive mould infections (IMIs)....
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Martin Hoenigl,
Reinhard B. Raggam,
Helmut J.F. Salzer,
Thomas Valentin,
Angelika Valentin,
Ines Zollner-Schwetz,
Anna T. Strohmeier,
Katharina Seeber,
Albert Wölfler,
Heinz Sill,
Robert Krause
et al.
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510-513
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| Short communications |
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Role of IncHI2 plasmids harbouring blaVIM-1, blaCTX-M-9, aac(6′)-Ib and qnrA genes in the spread of multiresistant Enterobacter cloacae and Klebsiella pneumoniae strains in different units at Hospital Vall d’Hebron, Barcelona, Spain
05 April 2012
Abstract: Seven Enterobacter cloacae isolates and seven Klebsiella pneumoniae isolates harbouring a phenotype compatible with the production of a metallo-β-lactamase were recovered between 2009 and 20...
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A. Coelho,
N. Piedra-Carrasco,
R. Bartolomé,
J.N. Quintero-Zarate,
N. Larrosa,
T. Cornejo-Sánchez,
G. Prats,
M.P. Garcillán-Barcia,
F. de la Cruz,
J.J. González-Lopéz
et al.
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514-517
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Emergence of a novel multidrug-resistant Pseudomonas aeruginosa strain producing IMP-type metallo-β-lactamases and AAC(6′)-Iae in Japan
09 April 2012
Abstract: The emergence of multidrug-resistant (MDR) Pseudomonas aeruginosa isolates producing IMP-type metallo-β-lactamases (MBLs) and aminoglycoside 6′-N-acetyltransferase [AAC(6′)-Iae] has become a...
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Tomoe Kitao,
Tatsuya Tada,
Masashi Tanaka,
Kenji Narahara,
Masahiro Shimojima,
Kayo Shimada,
Tohru Miyoshi-Akiyama,
Teruo Kirikae
et al.
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518-521
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High clonal heterogeneity of Panton–Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus strains from skin and soft-tissue infections in the Province of Bolzano, Northern Italy
05 April 2012
Abstract: Panton–Valentine leukocidin (PVL)-positive community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) isolates are widespread in many countries, with varying distribution and ...
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Richard Aschbacher,
Bruno Pichon,
Greta Spoladore,
Elisabetta Pagani,
Patrizia Innocenti,
Ludwig Moroder,
Mark Ganner,
Robert Hill,
Rachel Pike,
Oswald Ganthaler,
Leonardo Pagani,
Clara Larcher,
Angela Kearns
et al.
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522-525
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Characterisation and clonal dissemination of OXA-23-producing Acinetobacter baumannii in Tabriz, northwest Iran
23 April 2012
Abstract: The characteristics and molecular epidemiology of carbapenemase genes amongst 68 imipenem-resistant Acinetobacter baumannii isolated from Imam Reza Hospital (Tabriz, Iran) during a 17-month ...
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Amir Peymani,
Paul G. Higgins,
Mohammad-Reza Nahaei,
Safar Farajnia,
Harald Seifert
et al.
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526-528
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Identification and molecular characterisation of New Delhi metallo-β-lactamase-1 (NDM-1)- and NDM-6-producing Enterobacteriaceae from New Zealand hospitals
23 April 2012
Abstract: The global spread of New Delhi metallo-β-lactamase (NDM) is of significant public health concern. This study sought to determine whether blaNDM was present in Enterobacteriaceae isolates dis...
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Deborah A. Williamson,
Hanna E. Sidjabat,
Joshua T. Freeman,
Sally A. Roberts,
Anna Silvey,
Rosemary Woodhouse,
Eilidh Mowat,
Kristin Dyet,
David L. Paterson,
Timothy Blackmore,
Andrew Burns,
Helen Heffernan
et al.
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529-533
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Activity of ceftobiprole against Streptococcus pneumoniae isolates exhibiting high-level resistance to ceftriaxone
23 April 2012
Abstract: Tracking Resistance in the US Today (TRUST) 2008 surveillance data showed that 6% of Streptococcus pneumoniae were non-susceptible to ceftriaxone [minimum inhibitory concentration (MIC) ≥2μg...
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Todd A. Davies,
Robert K. Flamm,
A. Simon Lynch
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534-538
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| Letters to the Editor |
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2-Hydroxyisocaproic acid (HICA): a new potential topical antibacterial agent
09 April 2012
2-Hydroxyisocaproic acid (HICA), also known as leucic acid, 2-hydroxy-4-methylvaleric acid or 2-hydroxy-4-methylpentanoic acid, is a derivative of leucine with a molecular weight of 132.16g/mol. It is...
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M. Sakko,
L. Tjäderhane,
T. Sorsa,
P. Hietala,
A. Järvinen,
P. Bowyer,
R. Rautemaa
et al.
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539-540
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Plasmid-mediated quinolone resistance genes in enteroaggregative Escherichia coli from infants in Lima, Peru
23 April 2012
Since the description of the first horizontally transferable quinolone resistance mechanism in the late 1990s, several types of plasmid-mediated quinolone resistance (PMQR) genes have been described ,...
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Maribel Riveros,
Eleonora Riccobono,
David Durand,
Susan Mosquito,
Joaquim Ruiz,
Gian Maria Rossolini,
Theresa J. Ochoa,
Lucia Pallecchi
et al.
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540-542
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First report of a Pseudomonas aeruginosa clinical isolate co-harbouring KPC-2 and IMP-18 carbapenemases
23 April 2012
The Ambler class B metallo-β-lactamases such as IMP (31 IMP-like variants) and VIM (32 VIM-like variants), amongst others, and the class A Klebsiella pneumoniae carbapenemases (KPC-2 to KPC-12 variant...
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Teresa Martínez,
Guillermo J. Vázquez,
Edna E. Aquino,
Ramón Ramírez-Ronda,
Iraida E. Robledo
et al.
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542-543
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Sequence type 101 (ST101) as the predominant carbapenem-non-susceptible Klebsiella pneumoniae clone in an acute general hospital in Italy
25 April 2012
Klebsiella pneumoniae is one of the most common multidrug-resistant (MDR) Gram-negative organisms worldwide, responsible for high morbidity and mortality both in hospitals and alternative healthcare s...
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Caterina Mammina,
Celestino Bonura,
Aurora Aleo,
Teresa Fasciana,
Tamara Brunelli,
Giovanna Pesavento,
Roberto Degl’Innocenti,
Antonino Nastasi
et al.
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543-545
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Nosocomial occurrence of OXA-48-producing enterobacterial isolates in a Moroccan hospital
23 April 2012
Carbapenems possess the most powerful in vitro activity against extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae . Resistance to carbapenems is mediated mostly by two mechanisms: (i) ...
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Constantin Hays,
Amina Benouda,
Laurent Poirel,
Mostafa Elouennass,
Patrice Nordmann
et al.
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545-547
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