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Activity of JNJ-Q2, a new fluoroquinolone, tested against contemporary pathogens isolated from patients with community-acquired bacterial pneumonia
06 February 2012
Douglas J. Biedenbach, David J. Farrell, Robert K. Flamm, Lisa C. Liverman, Gail McIntyre, Ronald N. Jones
Abstract: JNJ-Q2 is a broad-spectrum fluoroquinolone with bactericidal activity against Gram-positive and Gram-negative pathogens and is currently in clinical development for the treatment of communit...
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Commentary on: Does empirical treatment of community-acquired pneumonia with fluoroquinolones delay tuberculosis treatment and result in fluoroquinolone resistance in Mycobacterium tuberculosis? Controversies and solutions
03 February 2012
Gabriel Levy Hara
The review in this journal by Shen et al. addresses one of the current controversies regarding antimicrobial therapy: which drug should be selected for the initial treatment of community-acquired pne...
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Does empirical treatment of community-acquired pneumonia with fluoroquinolones delay tuberculosis treatment and result in fluoroquinolone resistance in Mycobacterium tuberculosis? Controversies and solutions
27 January 2012
Gwan-Han Shen, Thomas Chang-Yao Tsao, Shang-Jyh Kao, Jen-Jyh Lee, Yen-Hsu Chen, Wei-Chung Hsieh, Gwo-Jong Hsu, Yen-Tao Hsu, Ching-Tai Huang, Yeu-Jun Lau, Shih-Ming Tsao, Po-Ren Hsueh
Abstract: The role of fluoroquinolones (FQs) as empirical therapy for community-acquired pneumonia (CAP) remains controversial in countries with high tuberculosis (TB) endemicity owing to the possibil...
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Cytosine deoxyribonucleoside anti-HIV analogues: a small chemical substitution allows relevant activities
24 January 2012
Francesco Scaglione, Liberato Berrino
Abstract: The search for new nucleoside analogue compounds targeting the virally encoded reverse transcriptase was developed by modifying the nucleoside structure to create inhibitor compounds. In thi...
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Antimicrobial susceptibility of Streptococcus pneumoniae isolates from vaccinated and non-vaccinated patients with a clinically confirmed diagnosis of community-acquired pneumonia in Belgium
16 January 2012
Ann Lismond, Sylviane Carbonnelle, Jan Verhaegen, Patricia Schatt, Annelies De Bel, Paul Jordens, Frédérique Jacobs, Anne Dediste, Frank Verschuren, Te-Din Huang, Paul M. Tulkens, Youri Glupczynski, Françoise Van Bambeke
Abstract: We assessed the in vitro susceptibility of Streptococcus pneumoniae isolates from patients with confirmed community-acquired pneumonia (CAP) to β-lactams, macrolides and fluoroquinolones and...
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