Inside this Issue
Functional role of UTX in normal and malignant hematopoiesis
See Liu et al., pages 487-498..Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX, also known as KDM6A), encodes an H3K27Me2/3 demethylase, which plays an important role in development, self renewal and cardiac differentiation. The UTX protein has tumor repressor properties, its deficiency results in embryonic lethality in mice, and somatic mutations have been identified in multiple hematological malignancies and many types of leukemia cell lines.
Improved cord blood engraftment: Ex vivo fucosylation revisited
See Robinson et al., pages 445-456..Advantages to HLA-matched unrelated donor CB transplants (UCBT) include a broad source of cells from worldwide public CB banks and relatively low rates of serious graft-versus-host disease (GvHD), due to the greater HLA disparity tolerated. However, a major obstacle slowing down the broader use of UCBT in adults remains the delayed engraftment resulting in significantly increased morbidity and mortality during the immediate post transplant period.
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The HDAC Inhibitor Givinostat Modulates the Hematopoietic Transcription Factors NFE2 and C-MYB in JAK2V617F Myeloproliferative Neoplasm Cells10 May 2012
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Low expression of asparagine synthetase in lymphoid blasts precludes its role in sensitivity to L-asparaginase27 April 2012
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How can we reduce hepatic veno-occlusive disease–related deaths after allogeneic stem cell transplantation?27 April 2012
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Drug-interaction studies evaluating T-cell proliferation reveal distinct activity of dasatinib and imatinib in combination with cyclosporine A20 April 2012
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In reply16 April 2012
